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CertifiedLabsWhat is Tissue Transglutaminase antibody IgA Test?
The Anti-Tissue Transglutaminase (tTG-IgA) test is a highly sensitive and specific blood test used to aid in the diagnosis of coeliac disease and dermatitis herpetiformis. Coeliac disease is an autoimmune disorder in which the immune system mistakenly reacts to gluten, a protein found in wheat, barley, rye, and oats. This immune response triggers the production of antibodies that target tissue transglutaminase (tTG), an enzyme in the intestinal lining.
This test is commonly performed in individuals with symptoms suggestive of coeliac disease or gastrointestinal trouble. It is also recommended for those with a family history of coeliac disease, thyroid disorders, type 1 diabetes, or other conditions linked to an increased risk of gluten sensitivity.
Individuals in Bangalore suspected to have gluten sensitivity or to be at risk of coeliac disease can schedule the Anti Tissue Transglutaminase test from the comfort of their home.
Tissue Transglutaminase antibody IgA Test Parameters
The tTG-IgA test detects the presence of IgA anti-tissue transglutaminase antibodies, which are key markers of coeliac disease.
These antibodies are produced when the immune system mistakenly attacks tTG in response to gluten ingestion. The test is widely used due to its high sensitivity and specificity (>90%) for diagnosing coeliac disease and monitoring disease activity.
IgA anti-tTG antibodies usually appear early in the disease process, sometimes even before symptoms develop. In most untreated coeliac patients, both IgA anti-tTG and IgA anti-endomysial antibodies are present. Following a gluten-free diet, IgA anti-tTG levels typically decrease and may eventually become undetectable. The parameter serves as a marker for dietary compliance and disease remission.
Tissue Transglutaminase antibody IgA Test Preparation
To prepare for the IgA anti-tTG test, check these testing prerequisites:
Prerequisites: Fasting is not necessary for the Anti Tissue Transglutaminase test.
Best Time to Get Tested: The Anti Tissue Transglutaminase test can be conducted at any convenient time during the day.
Who Should Get an Anti-Tissue Transglutaminase Test?: This test is recommended for individuals with symptoms of coeliac disease, such as chronic diarrhoea, abdominal pain, poor growth, or unexplained rashes. It is also advised for those with a family history of coeliac disease, autoimmune conditions like type 1 diabetes, or thyroid disorders.
Cautions Before Taking an Anti-Tissue Transglutaminase Test: To ensure accuracy, the test should be done while consuming a gluten-containing diet, as avoiding gluten may lead to falsely low antibody levels.
Why Take the Tissue Transglutaminase antibody IgA Test?
You may need an Anti-Tissue Transglutaminase test if you:
Experience symptoms of coeliac disease, such as:
Chronic diarrhoea
Abdominal pain
Bloating
Vomiting
Constipation
Poor growth
Skin rashes
Have a family history of coeliac disease, increasing your risk of developing the condition.
Have autoimmune conditions like type 1 diabetes or thyroid disorders, which are linked to coeliac disease.
FAQs on Tissue Transglutaminase antibody IgA Test in Bangalore
The cost of the Anti-Tissue Transglutaminase test in Bangalore is ₹1309. This includes home sample collection within 60 minutes, with test results available within 70 hours after sample collection.
Yes, Orange Health Labs offers home sample collection for the Anti-Tissue Transglutaminase test. A trained eMedic will visit your location within 60 minutes of booking to collect the sample.
This test is primarily used to diagnose and monitor coeliac disease by detecting IgA antibodies against tissue transglutaminase. It helps evaluate gluten sensitivity, confirm disease activity, and monitor response to a gluten-free diet. It may also be recommended for individuals with dermatitis herpetiformis or those at higher risk of coeliac disease due to genetic or autoimmune conditions.
Fasting is not necessary for the Anti Tissue Transglutaminase test.
To book an Anti-Tissue Transglutaminase test with Orange Health Labs, follow these steps:
Search & Select: Look for the "Anti-Tissue Transglutaminase test" and choose Orange Health Labs.
Confirm Appointment: Enter your details, select your location, and schedule a convenient time for sample collection.
Sample Collection: A trained eMedic will visit your home or office to collect the sample.
Laboratory Testing: The sample will be analysed at an NABL-accredited, ICMR-approved laboratory for antibody levels.
Receive Results: Test results will be delivered via email or WhatsApp within 70 hours.
Normal levels of IgA anti-tTG antibodies are typically negative. Positive levels or the presence of antibodies may indicate a strong likelihood of coeliac disease or gluten sensitivity.
The test results of the Anti-tTG IgA test are available within 70 hours of sample collection.
The frequency of testing depends on your doctor’s recommendation. It is commonly done at the time of suspected coeliac disease diagnosis and may be repeated periodically to monitor dietary compliance and disease activity in individuals on a gluten-free diet.
This test measures IgA anti-tTG antibodies, which indicate an immune response against tissue transglutaminase, a key marker for coeliac disease.
Orange Health Labs provides home sample collection for the Anti-Tissue Transglutaminase test across multiple localities in Bangalore, including but not limited to Adugodi, Banashankari, Bannerghatta, Basavanagudi, Bellandur, BTM Layout, Chamrajpet, Cottonpet, CV Raman Nagar, Frazer Town, Giri Nagar, Hebbal, Domlur, Electronic City, Hennur, Hosur, HSR Layout, Jakkur, Jalahalli, Jaya Nagar, Kadugodi, Kammanahalli, Kengeri, Koramangala, Mahalakshmi Layout, Madiwala, Magadi Road, Malleshwaram, Marathahalli, Mathikere, Mysore Road, Nagarbhavi, Nandhini Layout, Old Airport Road, Peenya, RT Nagar, Rajaji Nagar, Rajarajeshwari Nagar, Sadashivnagar, Sahakara Nagar, Sanjay Nagar, Sarjapur, Seshadripuram, Shanthi Nagar, Shivaji Nagar, Sri Nagar, Tyagarajnagar, Uttarahalli, Vasanth Nagar, Vidyaranyapura, Vijaya Nagar, Whitefield, Yelahanka, Yeshwantpur.
Payment & Refund Policy
- We do not accept cash payments
- All modes of online payment are accepted
- Refunds will be credited back to the source of payment within 5-7 working days of order cancellation.
References
- Blood Test: Tissue Transglutaminase IgA (tTg-IgA) (for Parents). Available from: https://kidshealth.org/en/parents/test-ttg.html
- Tissue Transglutaminase Antibody (TTG) - South Tees Hospitals NHS Foundation Trust. Available from: https://www.southtees.nhs.uk/services/pathology/tests/tissue-transglutaminase-antibody-ttg/
- Pathology Handbook. Available from: https://www.pathology.med.umich.edu/handbook/#/details/1217