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    What is an Extended Thyroid Profile Test?

    Thyroid tests are used to check the functionality of the thyroid, a butterfly-shaped gland at the front of the neck. This gland produces two important hormones—T3 (triiodothyronine) and T4 (thyroxine)—which regulate energy use in the body and affect various functions such as heart rate, digestion, weight, mood, and breathing. T3 is the active hormone influencing metabolism, while T4 serves as a reserve. Your doctor may order a thyroid test if you experience symptoms like fatigue, restlessness, irritability, sluggishness, or unexplained weight gain or loss. The test is useful for diagnosing thyroid conditions like hyperthyroidism (elevated hormone levels) and hypothyroidism (low hormone levels).

    The Extended Thyroid Profile includes tests for thyroid-stimulating hormone (TSH), total T4, total T3, free T4 (FT4), and free T3 (FT3). TSH, released by the pituitary gland, regulates the thyroid’s output of T3 and T4. While thyroid hormones circulate in both bound and free forms, only FT4 and FT3 can enter tissues and cause their effects.

    In bustling cities like Mumbai, symptoms of thyroid issues, such as tiredness or irritability, may go unnoticed. If you have these symptoms, an Extended Thyroid Profile test in Mumbai might be worth considering.

    Extended Thyroid Profile Test Parameters

    An Extended Thyroid Profile measures five important parameters for thyroid function assessment:

    TSH

    Produced by the pituitary, TSH stimulates thyroid hormone (T3 and T4) production.

    Total T4

    This parameter measures the total amount of T4, including its inactive bound form.

    Total T3

    This parameter evaluates the total T3, including the bound form that cannot enter tissues.

    Free T4

    Measures the unbound, biologically active form of T4 that can enter tissues.

    Free T3

    Determines the unbound T3, which is biologically active and capable of entering tissues.

    TSH regulates thyroid hormone levels through a feedback mechanism: low T4 increases TSH production, while high T4 decreases it. T4 is converted to T3 primarily in the liver and brain. This profile provides a complete picture of thyroid health for diagnosing thyroid disorders.

    Extended Thyroid Profile Test Preparation

    Consider the following points before scheduling an Extended Thyroid Profile test at home:

    • Prerequisites

    Fasting is typically not necessary for the Extended Thyroid Profile test. However, your doctor may sometimes recommend fasting for more precise results. Consult your doctor to find out if fasting is appropriate for your health condition.

    • Best Time to Get Tested

    It’s best to give a sample in the morning to avoid any impact from food on your thyroid results. Additionally, scheduling tests at the same time each day ensures consistency in tracking thyroid health.

    • Who Should Get an Extended Thyroid Profile Test

    If you are experiencing symptoms like fatigue, sluggishness, restlessness, irritability, or unexplained weight fluctuations, consider getting an Extended Thyroid Profile test. It is also recommended for those with a family history of thyroid issues, pregnant women, individuals with fertility concerns, or those undergoing treatment for thyroid disorders.

    • Cautions Before Taking an Extended Thyroid Profile Test

    This blood test does not require any prior preparation. However, inform your doctor about any medications you are taking, particularly those for thyroid disorders.

    Why Take a Extended Thyroid Profile Test?

    Thyroid hormone imbalances can negatively affect your well-being. An Extended Thyroid test might be required if you are:

    • Experiencing hyperthyroidism symptoms such as:

    • Rapid heartbeat

    • Excessive sweating

    • Heat sensitivity

    • Weight loss

    • Sleeping problems

    • Nervousness

    • Increased bowel movements

    • Light or absent menstruation

    • Experiencing hypothyroidism symptoms such as:

      • Slow heart rate

      • Dry skin

      • Cold sensitivity

      • Weight gain

      • Fatigue

      • Weakness

      • Muscle aches

      • Constipation

      • Heavy menstruation

    Furthermore, individuals with these conditions might also benefit from a Thyroid test:

    • Residence in an area without iodised salt, which increases the risk of iodine deficiency

    • Taking thyroid hormone replacement therapy

    • Pregnancy

    • Turner syndrome

    • Age over 60, particularly women

    • Undergoing infertility investigations

    • History of radiation therapy to the head and/or neck

    • Autoimmune diseases, such as:

      • Lupus

      • Rheumatoid arthritis

      • Pernicious anaemia

      • Type 1 diabetes

      • Celiac disease

      • Addison’s disease (primary adrenal insufficiency)

      • Sjögren’s syndrome

    Extended Thyroid Profile Test Results & Interpretation

    The table below provides the normal ranges for different parameters included in the Extended Thyroid Profile test:

    Test ParameterReference Range
    Triiodothyronine (T3), Free2.77-5.27 pg/mL
    Thyroxine (T4), Free0.78-2.19 ng/dL
    Triiodothyronine (T3), Total0.97-1.69 ng/dL
    Thyroxine (T4), Total5.53-11.0 µg/dL
    Thyroid Stimulating Hormone (TSH)0.400-4.049 µIU/mL

    However, in pregnant women, the reference range for TSH differs. For the precise values, please see the table below:

    TrimesterReference Range (µIU/mL)
    1st Trimester0.100-2.500
    2nd Trimester0.200-3.00
    3rd Trimester0.300-3.00

    Interpretation of Abnormal levels

    T4 and FT4

    Low T4/FT4 levels may indicate:

    • Hypothyroidism

    • Thyroiditis (inflammation of the thyroid gland)

    • Congenital hypothyroidism (present from birth in infants)

    • Medication side effects

    High T4/FT4 levels may indicate:

    • Hyperthyroidism

    • Excess dietary iodine

    • Overactive thyroid gland with a lump or areas that produce excess thyroid hormones (toxic nodule/goitre)

    • Thyroiditis

    • A tumour (noncancerous) in the pituitary gland

    T3 and FT3

    High T3/FT3 Levels:

    • Indicate hyperthyroidism

    • With normal or high TSH and high FT4 indicate a pituitary gland issue causing excess thyroid hormone secretion

    • With low TSH and high FT4 indicate a thyroid gland problem causing excess thyroid hormone secretion

    Low T3/FT3 Levels:

    • Indicate hypothyroidism

    • Normal or low T3 levels with high TSH and low FT4 point to a thyroid gland issue causing less secretion of thyroid hormone

    • Normal or low T3 levels with low TSH and low FT4 point to a pituitary gland problem causing less secretion of thyroid hormone

    TSH Levels

    High levels of TSH typically indicate primary hypothyroidism (caused due to issues in the thyroid gland).

    Low TSH levels suggest hyperthyroidism.

    Factors Influencing TSH Levels

    • Meal Timings and Circadian Rhythm : TSH levels can fluctuate with food intake and throughout the day. Significant variations are observed both with meal consumption and at different times of the day.

    • Additional Influences : TSH is a sensitive hormone influenced by factors beyond thyroid function. These include stress, physical activity, genetic factors, exposure to toxins and radiation, thyroid gland inflammation, iodine levels in the diet, pregnancy, non-thyroidal pituitary factors (such as glucocorticoids, somatostatin, and dopamine), and certain medications that can impact the TSH and free T4 relationship.

    FAQs on Extended Thyroid Profile Test in Mumbai

    The Extended Thyroid Profile test price is ₹ 1270. This price is inclusive of rapid home sample collection within 60 minutes of test booking, with results available in 6 hours.

    Yes, Orange Health Labs provides home sample collection services for the Extended Thyroid Profile test in Mumbai. Once the test is confirmed, your sample can be collected at home within 60 minutes, subject to available slots.

    The Extended Thyroid Profile test is used to:

    • Measure TSH, FT4, total T4, FT3, and total T3 to assess thyroid function.

    • Diagnose conditions such as hypo- and hyperthyroidism.

    • Monitor thyroid hormone therapy and evaluate pituitary gland conditions.

    • Identify thyroid inflammation, iodine imbalances, and possible tumours.

    No, you do not need to fast for an Extended Thyroid Profile test.

    To book a blood test or health checkup through our platform, follow these steps:

    • Search for the Test : Find the Extended Thyroid Profile test in Mumbai or for home collection, then visit Orange Health’s page from the results.

    • Review and Book : Select the test, review any prerequisites, enter your location, and confirm the booking by scheduling a suitable sample collection time.

    • Sample Collection : A trained eMedic will arrive at your home to collect the sample at the scheduled time.

    • Lab Processing : Your sample will be sent to an ICMR-approved and NABL-accredited lab for testing.

    • Get Results : Your reports will be delivered via email or WhatsApp within 6 hours and can also be viewed in our app.

    The normal levels for an Extended Thyroid Profile are:

    • FT3: 2.77-5.27 pg/mL

    • FT4: 0.78-2.19 ng/dL

    • Total T3: 0.97-1.69 ng/mL

    • Total T4: 5.53-11.0 µg/dL

    • TSH: 0.400-4.049 µIU/mL

    However, for pregnant women, the reference ranges for TSH levels vary by trimester, as follows:

    • 1st Trimester: 0.100 - 2.500 µIU/mL

    • 2nd Trimester: 0.200 - 3.000 µIU/mL

    • 3rd Trimester: 0.300 - 3.000 µIU/mL

    After booking the Extended Thyroid Profile test, an eMedic from Orange Health Labs will collect your sample within 60 minutes. The collection process usually takes just a few minutes. Your reports will be accessible online within 6 hours.

    The frequency of the Extended Thyroid Profile test is determined by your specific health needs. Be sure to follow your doctor’s instructions regarding how often you should be tested, based on your individual health condition.

    The Extended Thyroid Profile test includes the following 5 parameters:

    • Free T3

    • Total T3

    • Free T4

    • Total T4

    • TSH

    Orange Health provides the fastest Extended Thyroid Profile test services right at your home across Mumbai, removing the need for a physical lab visit. We cater to numerous localities, including but not limited to Colaba, Nariman Point, Marine Drive, Malabar Hill, Vashi, Belapur, Churchgate, Worli, Dadar, Parel, Byculla, Bandra, Andheri, Juhu, Ghatkopar, Powai, Chembur, Santacruz, Khar, Versova, Lokhandwala, Goregaon, Borivali, Kandivali, Mulund, Bhandup, Kurla.

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    References

    1. Thyroid Tests [Internet]. MedlinePlus.  Available from:  https://medlineplus.gov/thyroidtests.html
    2. Thyroid function tests [Internet]. Health Direct.  Available from:  https://www.healthdirect.gov.au/thyroid-function-tests
    3. Thyroid Hormone [Internet]. Cleveland Clinic.  Available from:  https://my.clevelandclinic.org/health/articles/22391-thyroid-hormone
    4. Thyroid Tests [Internet]. Cleveland Clinic.  Available from:  https://my.clevelandclinic.org/health/diagnostics/17556-thyroid-blood-tests