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    What is HLA-B27, Qualitative PCR Test?

    The HLA B27 Qualitative PCR Test is a blood test that is used to identify the presence of the HLA-B27 protein in white blood cells and diagnose autoimmune diseases. HLA-B27 has a crucial role in immune defence, but in some individuals, it is linked to an increased risk of autoimmune diseases. Autoimmune disorders arise when the immune system mistakenly attacks the body's healthy tissues, perceiving them as threats.

    Conditions commonly associated with HLA-B27 include:

    • Juvenile arthritis: An inflammatory joint disease occurring in children.

    • Ankylosing spondylitis: A type of arthritis that affects the spine, causing stiffness and pain.

    • Reactive arthritis: Joint inflammation triggered by an infection.

    A positive HLA-B27 result suggests a higher likelihood of developing autoimmune conditions but does not confirm a diagnosis, as many carriers never develop related diseases. Additional tests such as CRP, ESR, X-rays, MRI scans, and urine analysis may be needed for a comprehensive evaluation.

    A negative result indicates the absence of HLA-B27, lowering the probability of these conditions. In organ or tissue transplantation, mismatched HLA markers can lead to transplant rejection.

    For those in Hyderabad, the HLA B27 Qualitative PCR Test can be conducted at home with easy sample collection and prompt results.

    HLA-B27, Qualitative PCR Test Parameters

    The HLA B27 Qualitative PCR Test detects the presence of the HLA-B27 antigen on white blood cells. This antigen is part of the human leukocyte antigen (HLA) system, which enables the immune system to differentiate between the body’s cells and harmful invaders like viruses and bacteria.

    HLA proteins fall into two categories: Class I (A, B, C) and Class II (DR, DP, DQ). Though not as distinctive as fingerprints, these proteins vary from person to person and significantly influence immune responses.

    The presence of HLA-B27 is determined genetically and is inherited from parents. If a close family member has an HLA-B27-associated condition, such as ankylosing spondylitis, carrying this antigen may increase the risk of developing similar autoimmune diseases.

    There are around 15 known subtypes of HLA-B27, with HLA-B2705 and HLA-B2702 being the most frequently observed. Certain subtypes may be linked to a greater risk of developing autoimmune disorders. However, the relationship between HLA-B27 and disease is still being researched, and having this antigen does not necessarily indicate future illness. Nonetheless, its detection can assist in diagnosing specific autoimmune conditions.

    HLA-B27, Qualitative PCR Test Preparation

    If you’re planning to take the HLA B27 Qualitative PCR test at home, here are some key points to keep in mind:

    • Prerequisites : No fasting or special preparations are required before the test.

    • Best Time to Get Tested : This test can be taken at any time of the day, depending on your convenience.

    • Who Should Get a HLA B27 Qualitative PCR Test? : Testing is recommended for individuals experiencing chronic joint pain, swelling, stiffness, suspected autoimmune disorders, recurrent eye inflammation (uveitis), or those undergoing organ or tissue transplantation for compatibility assessment.

    • Cautions Before Taking a HLA B27 Qualitative PCR Test : There are no specific precautions to follow before taking this test.

    Why Take the HLA-B27, Qualitative PCR Test?

    The HLA-B27 test is recommended when autoimmune or inflammatory conditions are suspected. You may need this test if you experience:

    • Persistent joint pain, stiffness, or swelling, which could indicate an autoimmune disorder.

    • Chronic inflammation in the spine, neck, chest, eyes, or joints, often linked to conditions like ankylosing spondylitis or reactive arthritis.

    • Recurrent uveitis (eye inflammation) without an obvious cause, possibly associated with an immune system disorder.

    Additionally, this test is used for:

    • Screening for HLA-B27-related autoimmune diseases, such as ankylosing spondylitis, to assess potential risks.

    • Pre-transplant compatibility assessments, ensuring a match between a donor and recipient for organ or bone marrow transplants.

    It is often conducted alongside other tests like CCP antibody, CRP, ESR, rheumatoid factor, and imaging (X-rays) to evaluate inflammation and joint damage.

    FAQs on HLA-B27, Qualitative PCR Test in Hyderabad

    The cost of the HLA B27 Qualitative PCR test in Hyderabad is ₹2500, which includes quick home sample collection. A professional will arrive within 60 minutes of booking to collect the sample. Test results are typically available within 37 hours after the sample is processed at Orange Health Labs.

    Yes, Orange Health Labs provides home sample collection for the HLA B27 Qualitative PCR test. Once you book the test, a trained eMedic professional will reach your location within 60 minutes for a hassle-free sample collection.

    The HLA B27 Qualitative PCR test detects the presence of the HLA-B27 antigen, which is associated with autoimmune disorders such as ankylosing spondylitis, reactive arthritis, and psoriatic arthritis. It is also used to assess compatibility in organ transplants.

    No, fasting is not necessary for this test. It can be taken at any time of the day without any special dietary restrictions.

    Booking the HLA B27 Qualitative PCR test with Orange Health Labs is quick and simple:

    • Find the Test: Search for "HLA B27 Qualitative PCR test" and select Orange Health Labs from the available options.

    • Confirm Your Booking: Provide your details, choose your location, and select a suitable time for sample collection.

    • Sample Collection: A certified eMedic professional will visit your home to collect the required blood sample.

    • Testing & Results: Your sample will be processed at an NABL-accredited, ICMR-approved lab, and results will be shared via email or WhatsApp within 37 hours.

    The HLA-B27 Qualitative PCR test provides either a positive or negative result. A negative result is considered normal and suggests a lower likelihood of HLA-B27-associated autoimmune disorders. A positive result indicates the presence of the HLA-B27 antigen, which may increase the risk of autoimmune diseases, but it does not confirm a diagnosis.

    The test results are usually available within 37 hours after the sample has been collected.

    The need for repeat testing depends on your health status, symptoms, and doctor's recommendations. If required, your doctor will guide you on when to take the test again.

    This test checks for a single parameter—the presence of the HLA-B27 antigen in your blood, which is associated with certain autoimmune disorders.

    The HLA B27 Qualitative PCR test is available in multiple locations across Hyderabad, including but not limited to Banjara Hills, Jubilee Hills, Gachibowli, Madhapur, Hitech City, Kondapur, Begumpet, Somajiguda, Ameerpet, Panjagutta, Kukatpally, Miyapur, Manikonda, Secunderabad, Tarnaka, Abids, Koti, Mehdipatnam, Dilsukhnagar, Uppal, LB Nagar, Nallagandla, Nizampet, Attapur, Malkajgiri.

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    References

    1. HLA-B27 antigen: MedlinePlus Medical Encyclopedia.  Available from:  https://medlineplus.gov/ency/article/003551.htm
    2. HLA-B27 Antigen.  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?ContentTypeID=167&ContentID=hla_b27_antigen
    3. Human leukocyte antigen (HLA) B27 | Pathology Tests Explained.  Available from:  https://www.pathologytestsexplained.org.au/ptests-pro.php?q=HLA+B27