Weight gain is often driven by underlying biological factors that go undetected in routine blood tests. Identifying these root causes is the first step towards an effective, personalised weight loss plan. Orange Health Labs’ Pre-Weight Loss Checkup is a comprehensive 74-parameter diagnostic package designed by doctors to uncover WHY a person is gaining or unable to lose weight. It evaluates insulin resistance (HOMA-IR), stress hormones (Cortisol), systemic inflammation (hsCRP), thyroid function, liver and kidney health, lipid levels, blood sugar control (HbA1c), pancreatic enzymes (Amylase and Lipase), and key vitamins (D and B12). This package gives your doctor a complete metabolic picture to build a targeted, data-driven weight loss plan instead of a one-size-fits-all approach.

A few points to be considered before doing a Pre-Weight Loss Checkup at home are as follows:

Prerequisites

Fasting for 8–12 hours is mandatory before this checkup. This is required for accurate HOMA-IR (insulin resistance), fasting blood sugar, and lipid profile results. You may drink plain water during the fasting period.

Best Time to Get Tested

This checkup should ideally be done in the morning between 7 AM and 10 AM, as fasting overnight makes morning collection most convenient and ensures accurate cortisol and insulin readings.

Who Should Avail This Checkup

This checkup would be beneficial for:

• People who have been struggling to lose weight despite diet and exercise, and want to find out if an underlying metabolic or hormonal issue is the cause.

• People who are planning to start a structured weight loss program, join a clinic, or consult a dietitian, and want a complete metabolic baseline before beginning.

• People who are considering or about to start GLP-1 medications (such as Ozempic or Mounjaro) and need a pre-therapy assessment of their metabolic, liver, kidney, and thyroid health.

• People who want to understand the biological factors behind their weight gain, even if they are not planning to start a specific weight loss program right away.

Cautions Before Taking This Checkup

This checkup includes several types of tests, so it’s important to know that some medications or supplements may affect the results. You should notify your treating doctor about any drugs or supplements you are taking.

A Pre-Weight Loss Checkup is a crucial first step before starting any weight loss journey. It allows for:

• Identification of root causes of weight gain such as insulin resistance, thyroid dysfunction, and hormonal imbalances

• A complete metabolic and safety baseline before starting a diet plan, fitness program, or medical intervention such as GLP-1 medications

• Detection of inflammation and nutritional deficiencies that silently sabotage weight loss efforts

• Data-driven conversations with your doctor or dietitian, replacing guesswork with clinical evidence