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    What is Tissue Transglutaminase antibody IgA Test?

    The Anti-Tissue Transglutaminase (tTG-IgA) test is a reliable and accurate blood test used to detect coeliac disease and dermatitis herpetiformis. Coeliac disease is an autoimmune condition where the body mistakenly views gluten—a protein found in wheat, barley, rye, and oats—as a threat. This triggers the immune system to produce antibodies that attack tissue transglutaminase (tTG), an enzyme critical for maintaining a healthy intestinal lining.

    The tTG-IgA test is often recommended for individuals with persistent digestive problems or signs suggestive of coeliac disease. It is also advised for people with a genetic predisposition to gluten intolerance, thyroid issues, type 1 diabetes, or autoimmune disorders associated with gluten sensitivity.

    Residents in Noida suspecting gluten sensitivity or coeliac disease can easily book an Anti-Tissue Transglutaminase test from the convenience of their homes, ensuring timely diagnosis and management.

    Tissue Transglutaminase antibody IgA Test Parameters

    The tTG-IgA test measures antibodies called IgA anti-tissue transglutaminase, which serve as important markers of coeliac disease.

    These antibodies develop when the immune system mistakenly attacks tissue transglutaminase (tTG), an enzyme essential for intestinal health, after gluten consumption. The test is over 90% reliable for identifying coeliac disease and monitoring its progression.

    In many cases, these antibodies appear early, sometimes even before symptoms such as bloating or diarrhoea are evident. For untreated individuals, both IgA anti-tTG and IgA anti-endomysial antibodies are frequently present. A gluten-free diet gradually reduces these antibody levels, which may disappear altogether with strict dietary compliance.

    This test is useful in confirming the presence of coeliac disease and tracking the effectiveness of a gluten-free diet for long-term disease control.

    Tissue Transglutaminase antibody IgA Test Preparation

    Preparing for the IgA anti-tTG test is simple, just make sure to follow these essential guidelines:

    • Prerequisites: The Anti-Tissue Transglutaminase test does not require fasting.

    • Best Time to Get Tested: You can take the Anti-Tissue Transglutaminase test at any time of the day that fits into your schedule.

    • Who Should Get an Anti-Tissue Transglutaminase Test?: This test is ideal for people with symptoms like chronic diarrhoea, persistent stomach pain, poor growth in children, or unexplained rashes. It’s also suggested for individuals with a family history of gluten-related disorders or autoimmune conditions such as type 1 diabetes and thyroid disease.

    • Cautions Before Taking an Anti-Tissue Transglutaminase Test: To ensure reliable results, it’s essential to maintain a gluten-containing diet before the test. Cutting out gluten may cause antibody levels to drop, leading to incorrect findings.

    Why Take the Tissue Transglutaminase antibody IgA Test?

    The Anti-Tissue Transglutaminase test is suggested if you:

    ● Have autoimmune conditions, such as type 1 diabetes or thyroid disorders, as these are closely associated with coeliac disease.

    ● Experience symptoms often linked to coeliac disease, including:

    o Persistent diarrhoea

    o Vomiting

    o Constipation

    o Bloating

    o Slowed growth

    o Chronic abdominal discomfort

    o Recurrent skin rashes

    ● Have a family history of coeliac disease, which increases your chances of developing it.

    FAQs on Tissue Transglutaminase antibody IgA Test in Noida

    The cost of the Anti-Tissue Transglutaminase test in Noida is ₹1309. This price includes hassle-free home sample collection, which is completed within 60 minutes of booking, with results delivered within 131 hours of collection.

    Yes, Orange Health Labs offers a convenient home collection service for the Anti-Tissue Transglutaminase test. Their trained eMedic will reach your chosen location within 60 minutes to collect the sample securely and efficiently.

    This test is used to identify IgA antibodies against tissue transglutaminase, helping in the diagnosis of coeliac disease or gluten sensitivity. It is also employed for tracking dietary adherence in gluten-free regimens and diagnosing related conditions like dermatitis herpetiformis and autoimmune disorders.

    No, fasting is not needed for the Anti-Tissue Transglutaminase test. You can eat normally prior to the test.

    You can schedule an Anti-Tissue Transglutaminase test with Orange Health Labs by following these simple steps:

    • Search and Select: Look for the "Anti-Tissue Transglutaminase Test" on Orange Health Labs' website or app.

    • Confirm Details: Input your personal information, select your preferred location, and book a suitable time slot.

    • Sample Collection: A trained eMedic will visit your home or office to collect the sample in a safe and hygienic manner.

    • Laboratory Analysis: The sample will be processed in an NABL-accredited and ICMR-approved laboratory.

    • Receive Results: Your test report will be sent to your email or WhatsApp within 131 hours.

    Typically, IgA anti-tTG levels are negative in healthy individuals. A positive test result could strongly indicate gluten sensitivity or coeliac disease.

    In Noida, test reports are made available within 131 hours after the sample is collected.

    The frequency of this test is based on your doctor’s advice. It is usually performed at diagnosis and may be repeated regularly to check adherence to a gluten-free diet and monitor disease progression.

    This test measures the IgA anti-tTG antibodies, which help detect immune reactions against tissue transglutaminase, a vital marker for identifying coeliac disease.

    Orange Health Labs provides convenient home sample collection services across various areas in Noida, including Sector 1, Sector 15, Sector 18, Sector 26, Sector 37, Sector 50, Sector 62, Sector 76, Sector 93, Sector 100, Sector 104, Sector 110, Sector 120, Sector 128, Sector 137, Sector 150, Sector 168, Sector 71, Sector 63, Sector 22, Sector 41, Sector 108, Sector 47, Sector 121, Sector 45.

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    References

    1. Blood Test: Tissue Transglutaminase IgA (tTg-IgA) (for Parents).  Available from:  https://kidshealth.org/en/parents/test-ttg.html
    2. Tissue Transglutaminase Antibody (TTG) - South Tees Hospitals NHS Foundation Trust.  Available from:  https://www.southtees.nhs.uk/services/pathology/tests/tissue-transglutaminase-antibody-ttg/
    3. Pathology Handbook.  Available from:  https://www.pathology.med.umich.edu/handbook/#/details/1217