What is a Liver Function Test (LFT) test?
A liver function test (LFT) includes a group of blood tests commonly performed to evaluate the function of the liver. This tests measure the level of enzymes and proteins produced by the liver functions including bilirubin, albumin, etc. It is been advised in case of symptoms suggestive of liver problems such as dark urine, diarrhoea, light stool, and jaundice.
LFT helps in the diagnosis of liver conditions including liver cirrhosis, hepatitis, and liver damage. It was also been advised to patients undergoing treatment for liver disorders.
When is a Liver Function Test (LFT) test recommended?
A liver function test is often recommended in the following situations: to check for damage from liver infections, such as hepatitis B and hepatitis C, especially if it’s suspected you were exposed to a virus that causes hepatitis to monitor the side effects of certain medications because some medications are known to affect the liver, including statins, antibiotics, anti seizure medications, tuberculosis drugs.
If you already have liver disease, monitor the disease and how well a particular treatment is working. if you’re experiencing the symptoms of a liver disorder or have a family history of liver disease, such as fatty liver disease, if you have certain medical conditions, such as a high triglycerides, diabetes, high blood pressure and anemia, if you are drinking alcohol frequently, if you have gallbladder disease.
Certain tests can be reflected in different aspects of liver functions. For example, elevated alanine transaminaseTrusted Source and aspartate transaminase disproportional to bilirubin and alkaline phosphatase levels often indicate liver disease.
What does it Measure?
Liver function tests measures the level of liver enzymes, proteins, and bilirubin in the blood. The liver helps in the synthesis of certain proteins, produces bile (an alkaline compound that helps in the breakdown of fat), processes the bilirubin a yellowish substance produced from the breakdown of haemoglobin, and it helps in removing ammonia and other toxins (harmful substances) from the body. It plays an important role in the metabolism of fats, protein and carbohydrates. It stores glycogens, vitamins, and minerals as well as it helps in the metabolism (breakdown) of certain drugs.
Many of the diseases affects the health of the liver like hepatitis A, hepatitis B, hepatitis C, alcoholic hepatitis, autoimmune hepatitis, cirrhosis, non-alcoholic fatty liver disease (NAFLD), bile duct obstruction, liver or bile duct cancer, and many others. Liver functions can also be affected by the various risk factors like alcohol, certain drugs, sedentary lifestyle, and obesity. Regular monitoring of liver function helps in essentials for the early detection of any liver abnormalities.
LFT is a group of tests that measure the levels of (SGOT) Aspartate Aminotransferase (AST), (SGPT) Alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP), Total protein, Bilirubin and Gamma Glutamyl transferase (GGT) in blood. Each component has its significance and helps to understand a particular aspect of the liver function.
Alanine Aminotransferase (ALT) - Alanine Aminotransferase (ALT) is an enzyme and this test measures the level of the enzymes in the blood. ALT is also known as serum glutamic pyruvic transaminase (SGPT) and is mainly found in the liver, but it is also a smaller amounts in the kidneys, heart, pancreas and muscles. The enzymes is released into the bloodstream in case of liver disease or damage leading to increased ALT blood levels, a specific indicator of liver injury. However, this test cannot determine the severity of the liver damage.
Aspartate Aminotransferase (AST) - This test measures the level of the enzyme AST in your blood. This is also known as serum glutamate oxaloacetate transaminase (SGOT) test. AST is found in the liver and is released into the blood in large amounts in case of liver injury. AST levels are usually measured along with ALT as AST is not specific for the liver (also found in the heart, skeletal muscle and other organs).
Alkaline phosphatase (ALP) - This test measures the blood levels of the enzyme ALP which is found in the liver (one of the main sources), bile ducts, bones, intestine, pancreas and kidney. ALP helps in breakdown of proteins in the body. Diseases that mainly harm or damage the cells of the liver and bile duct, lead to overproduction and release of this enzyme into the bloodstream. This causes increased blood ALP levels.
Serum Total Protein - The total amount of proteins is measured in the blood, which includes two major types of proteins: albumin and globulin. The test reports mention separate results for total protein, albumin, globulin and albumin/globulin ratio (A/G ratio). The protein levels in the blood that indicates the biosynthetic capacity of the liver. Hepatocytes (liver cells) are unable to synthesise this protein in certain liver diseases leading to a fall in protein levels in the blood. Albumin is synthesised only in the liver. It helps in transporting minerals, enzymes, hormones, bilirubin and some medicines throughout your body. It prevents the fluid leaking out from your blood vessels into the tissues. Globulin is synthesised in the liver and by the cells through the immune system. It plays a key role in fighting other infections and transports mo enzymes, hormones, minerals and some medicines in the body.
Bilirubin - Measures the amount of bilirubin in the blood. Bilirubin is the waste product derived from the breakdown of red blood cells and is processed by the liver. Bilirubin blood test report includes separate values for direct bilirubin (conjugated), indirect bilirubin (unconjugated), and total bilirubin. When heme is released from the haemoglobin, it is converted to bilirubin. This is called unconjugated (indirect) bilirubin which is carries to the liver by few proteins. In the liver, bilirubin gets attached (conjugated bilirubin) to modified sugar (glucuronic acid) and forms conjugated (direct) bilirubin. Both these tests can be measured or estimated by laboratory, and the total bilirubin result (includes both direct and indirect bilirubin) is also measured. A damaged liver cannot properly process bilirubin, leading to abnormally high levels of bilirubin in the blood. Increased unconjugated bilirubin in the blood results due to its over production or improper uptake by the liver. Increased conjugated bilirubin results can be seen in diseases that reduce the rate of secretion of conjugated bilirubin into the bile or the flow of bile juice into the intestine resulting in an backward flow of conjugated bilirubin into the blood.
Gamma-glutamyltransferase (GGT) - GGT test measures the level of the GGT enzyme in your blood which is present in large amounts in the liver. It is a transport molecule and it helps the liver to metabolise many drugs and toxins. GGT is a very sensitive test for detecting any liver disorder especially due to intake of alcohol abuse and is also one of the first enzymes to rise in patients with bile duct obstruction like tumour or stones.
How long will the reports take?
You will get the reports within 6 hours after collection of the blood sample.
What is the cost of the Liver Function test (LFT)?
The cost of the Liver Function test (LFT) test in Noida is Rs. 700.
How often should I get tested for Liver Function Test (LFT)?
A liver function test is prescribed by your doctor after a complete assessment of your symptoms and conditions.
What are the normal values for an Liver Function Test (LFT) Test?
The Normal values are as follows:
Alanine Aminotransferase (ALT) - 0-35 U/L.,
Aspartate Aminotransferase (AST) - 0-35 U/L.,
Alkaline phosphatase (ALP) - 30-120 U/L,
Total Serum Protein - 5.5-8.0 g/dL,
Albumin 3.5-5.5 g/dL,
Globulin 2.0-3.5 g/dL,
Total Bilirubin 0.3-1.0 mg/dL,
conjugated bilirubin (direct) 0.1-0.3mg/dL,
unconjugated bilirubin (indirect) is 0.2-0.7mg/dL,
GGT 9-48 U/L.
What is the type of sample required?
We require blood for this test.
What time should I get the test done?
This test can be taken at any time during the day.
Is Fasting required for Liver function Test (LFT)?
Fasting is not required. It Depends on whether your doctor may ask you to fast for 10 to 12 hours or to do after food before the test without taking food, drinks, or medicines.
Any other precautions to be taken before getting myself tested for Liver Function Test (LFT)?
Since some foods and medicines may interfere with your test results, It Depends on your doctor may ask you to stop eating the food before the test without taking food, drinks, or medicines.
How can I book a Liver function Test (LFT) in Noida?
Log into www. orange health. in and submit your details. Our highly trained, professional, and vaccinated eMedics will be at your doorstep within 60 minutes or at the time booked by you.
Why should I book a Liver Function Test (LFT) with Orange Health in Noida?
Orange Health is the Fastest Diagnostic Lab. With us, you can get tested at home within 60 minutes of placing an order anywhere in Noida. Our trained, professional and vaccinated e Medic will be at your doorstep at the time selected by you.
Your sample is safely transported at the optimal temperature to our NABL accredited and ICMR approved lab. The results will be delivered to you faster too!
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