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    What Is a CD 19, Flow Cytometry Test?

    The CD19 blood test measures the concentration of CD19, a protein located on the surface of B cells, which are a type of white blood cell crucial for immune function. CD19 plays a significant role in regulating B cell activity, assisting their growth, division, and response to infections. This protein is present in both healthy B cells and certain cancers, particularly B-cell-related cancers such as leukaemia and lymphoma. The main purpose of the CD19 blood test is to detect and monitor B-cell-related cancers, including:

    • B-cell Acute Lymphoblastic Leukaemia (B-ALL): A type of cancer characterised by the uncontrolled multiplication of abnormal B cells.

    • Chronic Lymphocytic Leukaemia (CLL): A blood and bone marrow cancer that mostly affects older adults.

    • B-cell Lymphomas: A type of cancer affecting the lymphatic system that involves B cells.

    As CD19 is present on the surface of most B-cell tumours, this test helps identify abnormal B cells and track whether the disease is progressing or spreading. CD19 levels vary across cancers; elevated levels are found in breast, liver, pancreatic, and adrenal cancers, while lower levels may be seen in cervical cancer and sarcoma, which can result in poorer outcomes. The CD19 Marker Flow Cytometry test may also help predict how well a patient will respond to treatment. In addition to cancer, CD19 may be associated with other conditions, such as psoriasis and major depressive disorder (MDD), via specific immune signalling pathways.

    For individuals in Noida, a home test for CD19 is available with convenient sample collection and swift delivery of results.

    CD 19, Flow Cytometry Test Parameters

    The CD19 test measures one key parameter: the presence of the CD19 protein on B cells in the blood. CD19 is a protein located on the surface of B cells, and it plays a crucial role in enabling B cells to respond effectively to infections. It works in conjunction with other proteins, including the B cell receptor (BCR), to activate B cells when required. This activation supports B cell growth and the production of antibodies to combat infections.

    CD19 is present at various stages of B cell development, starting from the bone marrow, where B cells are produced, to the spleen, where they mature. It is essential for the proper function and maturation of B cells. Beyond its role in immune response, CD19 is also present in many B-cell-related cancers, such as leukaemia and lymphoma, assisting in diagnosis and helping to inform treatment decisions. As CD19 is specific to B cells, it is targeted by certain treatments that utilise the body’s immune cells to fight cancer.

    CD 19, Flow Cytometry Test Preparation

    To prepare for the CD19 test at home, the following prerequisites apply:

    • Prerequisites

    There are no specific requirements, such as fasting, for the CD19 test.

    • Best Time to Get Tested The CD19 test can be scheduled and conducted at any time throughout the day that is convenient for you.

    • Who Should Get a CD19 Test? This test is highly recommended for those with frequent infections, suspected immune system disorders, autoimmune conditions, or B cell cancers like leukaemia and lymphoma, to assess immune health and monitor disease progression.

    • Cautions Before Taking a CD19 Test No special precautions are needed before undergoing the CD19 test.

    Why Take the CD 19, Flow Cytometry Test?

    The CD19 test is valuable for identifying and monitoring certain diseases, particularly those affecting B cells. It serves several purposes:

    • Identifying Blood Cancers : Some cancers, such as acute lymphoblastic leukaemia (ALL), chronic lymphocytic leukaemia (CLL), and B-cell lymphomas, are linked to elevated CD19 levels. This test aids in early detection of these diseases.

    • Distinguishing Lymphoma Types : Various types of lymphoma (a blood cancer) present different CD19 levels. The test helps pinpoint the exact type, which is crucial for selecting the appropriate treatment.

    • Monitoring Cancer Progression : For patients undergoing treatment for blood cancers, the test provides insight into whether the disease is improving or worsening over time.

    • Predicting Cancer Prognosis : Certain cancers, such as cervical cancer, rectal cancer, and sarcoma, often show low CD19 levels when the disease is more advanced. This test helps assess the severity of the disease.

    • Examining Other Cancers : High CD19 levels are also observed in cancers like breast cancer and liver cancer.

    The CD19 Marker Flow Cytometry test plays a vital role in diagnosing, monitoring, and researching various cancers by detecting B-cell changes, tracking disease progression, and identifying cancer types.

    FAQs on the CD 19, Flow Cytometry Test in Noida

    The cost of the CD19 test in Noida is ₹2890. This fee includes quick home sample collection within 60 minutes of booking. The results will be provided within 108 hours after the sample is collected.

    Yes, Orange Health Labs offers home sample collection for the CD19 test. After booking, a qualified eMedic professional will visit your home within 60 minutes to collect the sample.

    A CD19 test is used to evaluate B cell function, aiding in the diagnosis of immune system disorders, infections, and specific blood cancers such as lymphoma and leukaemia.

    No, fasting is not necessary before the CD19 test, so you can take the test without any specific preparation.

    To book a CD19 test with Orange Health Labs, simply follow these steps:

    • Search for the Test : Look for the "CD19 test" and select the Orange Health Labs option from the results.

    • Confirm Your Booking : Enter your details, choose the correct location, and select a convenient time for sample collection.

    • Sample Collection : A qualified eMedic will visit your location to collect the blood sample.

    • Analysis and Results : The sample will be processed at our NABL-accredited, ICMR-approved laboratory. You will receive the results via email or WhatsApp within 108 hours of sample collection.

    The normal range for CD19 test results is 4.6–22.1% for the percentage of CD19 cells, and 56.6–417.4 cells/µL for the absolute count of CD19 cells.

    Test results are typically available within 108 hours after the sample is collected.

    The frequency of the CD19 test depends on your individual health condition and your doctor's recommendation.

    The CD19 test measures two parameters: the percentage and absolute count of CD19 cells present on the surface of B cells in your bloodstream.

    The CD19 test is available in several areas across Noida, including but not limited DLF Phase 1, DLF Phase 2, DLF Phase 3, DLF Phase 4, DLF Phase 5, Sector 14, Sector 15, Sector 21, Sector 22, Sector 23, Sector 24, Sector 29, Sector 31, Sector 40, Sector 42, Sector 43, Sector 45, Sector 46, Sector 50, Sector 51, Sector 52, Sector 53, Sector 54, Sector 55, Sector 56.

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    References

    1. Wang K, Wei G, Liu D. CD19: a biomarker for B cell development, lymphoma diagnosis and therapy. Experimental Hematology & Oncology.  Available from:  https://ehoonline.biomedcentral.com/articles/10.1186/2162-3619-1-36
    2. Zhou B, Wu T, Li H, Yang J, Ma Z, Ling Y, et al. Identification of CD19 as a shared biomarker via PPARγ/β-catenin/Wnt3a pathway linking psoriasis and major depressive disorder. Journal of Affective Disorders.  Available from:  https://www.sciencedirect.com/science/article/abs/pii/S0165032724013958
    3. CD19 - an overview | ScienceDirect Topics [Internet].  Available from:  https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/cd19