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    What is CA 15.3, Breast Cancer Marker Test?

    The CA 15-3 test measures the amount of Cancer Antigen 15-3 in the blood. This glycoprotein is commonly used as a tumor marker to follow up on breast cancer patients, specifically to evaluate treatment efficacy, detect relapses, and occasionally aid in early detection. However, its use in primary diagnosis is limited due to reduced sensitivity and specificity.

    Individuals diagnosed with advanced breast cancer, who are recommended to monitor disease progression, may schedule a convenient at-home CA 15-3 (Breast Cancer Marker) test.

    CA 15.3, Breast Cancer Marker Test Parameters

    The CA 15.3 (Breast Cancer Marker) test evaluates levels of the CA 15.3 marker in the bloodstream.

    CA 15.3 is a protein secreted by certain types of cells, primarily breast cancer cells, and enters the bloodstream. This marker is widely used to track the progression of breast cancer and evaluate responses to various treatments.

    Elevated CA 15.3 levels are commonly linked to advanced or metastatic breast cancer. Other causes of increased CA 15.3 include ovarian, prostate, or lung cancers, as well as non-malignant conditions such as pelvic inflammatory disease, benign breast or ovarian disorders, liver disease, pregnancy, and lactation. CA 15.3 levels can also rise in benign conditions like endometriosis or other inflammatory diseases.

    Limitations of the Test Include:

    Lacks Specificity

    Although CA 15.3 is mainly connected to breast cancer, its limited sensitivity and specificity mean other cancers or benign conditions may also result in raised levels.

    Not for Screening

    Routine screening or early detection of breast cancer is not recommended using this test. It is typically reserved for monitoring patients already diagnosed with cancer.

    False Negatives Possible

    In some situations, CA 15.3 levels may remain normal, even when cancer is present, especially in localised or early stages of the disease.

    CA 15.3, Breast Cancer Marker Test Preparation

    Ensure proper preparation for the CA 15.3 (Breast Cancer Marker) test by following these guidelines:

    • Prerequisites : There is no requirement to fast before taking the CA 15.3 (Breast Cancer Marker) test.

    • Best Time to Get Tested : The CA 15.3 (Breast Cancer Marker) test can be conducted at a time that works best for you and your routine.

    • Who Should Get a CA 15.3 (Breast Cancer Marker) Test : This test is helpful for patients receiving treatment for advanced or metastatic breast cancer to monitor treatment efficacy. It is also advised for individuals with a history of breast cancer to check for recurrence.

    • Cautions Before Taking a CA 15.3 (Breast Cancer Marker) Test : Inform your physician about any medications or medical conditions that could potentially impact the results of the test. Keep in mind that elevated CA 15.3 levels can occur due to non-cancerous factors, including lactation, pregnancy, or benign breast disorders.

    Why Take the CA 15.3, Breast Cancer Marker Test?

    The CA 15.3 test is a very useful test for managing breast cancer, especially for those with metastatic or advanced disease. Here’s why you might need this test:

    • Evaluate Breast Cancer Treatment: Regular measurements of CA 15-3 levels during or post-treatment provide valuable insights into treatment effectiveness.

    • Detect Potential Recurrence: Elevated CA 15-3 levels in patients with a breast cancer history could signal a possible recurrence, though this must be confirmed with imaging and biopsies.

    • Prognosis Assessment: Evidence suggests higher CA 15-3 levels during diagnosis or treatment might indicate a worse prognosis, but such findings require cautious interpretation.

    • Metastatic Cancer Tracking: It is beneficial for tracking metastatic breast cancer progression, especially when combined with tests for HER2 and hormone receptor status.

    • Metastasis Diagnosis Support: When combined with imaging techniques and other tumour markers, the CA 15-3 test aids in identifying breast cancer metastases cost-effectively.

    • Guide Disease Management Decisions: The test provides valuable information on disease progression, supporting necessary changes in treatment protocols at the right time.

    FAQs on CA 15.3, Breast Cancer Marker Test in Gurgaon

    In Gurgaon, the CA 15.3 test is priced at ₹1350. The fee includes quick home sample collection within 60 minutes after booking and delivery of results within 45 hours.

    Yes, Orange Health Labs offers convenient home sample collection for the CA 15.3 test. A trained eMedic will arrive within 60 minutes to collect your sample.

    This test helps monitor breast cancer, track the effectiveness of treatment, and identify cancer recurrence, primarily in metastatic conditions. It is unsuitable for early diagnosis or general breast cancer screening.

    No fasting is required for this test. You can schedule it at a time that is convenient for you.

    Booking a CA 15.3 (Breast Cancer Marker) Test with Orange Health Labs is simple:

    • Locate the Test: Search for "CA 15.3 (Breast Cancer Marker) Test" and select Orange Health Labs from the list.

    • Confirm Details: Enter your location, preferred time for sample collection, and confirm the booking.

    • Sample Collection: A certified eMedic will visit your home to collect the sample.

    • Laboratory Analysis: The sample is processed at our NABL-accredited and ICMR-approved lab.

    • Results Delivery: The results will be sent via email or WhatsApp within 45 hours of sample collection.

    Normal CA 15.3 levels are generally under 35 U/mL. Raised levels might indicate breast cancer progression or recurrence. Seek guidance from your doctor for correct interpretation.

    Test results for the CA 15.3 test are typically provided within 45 hours after the sample has been collected.

    The timing of repeat tests is determined by your doctor based on the treatment plan and disease monitoring needs. It is commonly done periodically to track progress.

    The CA 15.3 test measures a single marker: cancer antigen 15-3, which is a protein frequently associated with advanced-stage breast cancer.

    Orange Health offers CA 15.3 testing with home sample collection services in Gurgaon. Coverage includes areas such as DLF Phase 1, DLF Phase 2, DLF Phase 3, DLF Phase 4, DLF Phase 5, Sector 14, Sector 15, Sector 21, Sector 22, Sector 23, Sector 24, Sector 29, Sector 31, Sector 40, Sector 42, Sector 43, Sector 45, Sector 46, Sector 50, Sector 51, Sector 52, Sector 53, Sector 54, Sector 55, Sector 56.

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    References

    1. CA 15-3. 2024  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=167&contentid=ca_15_3
    2. Cancer antigen 15-3 (CA15-3) test [Internet]. Canadian Cancer Society.  Available from:  https://cancer.ca/en/treatments/tests-and-procedures/cancer-antigen-15-3-ca-15-3
    3. Prognostic Impact of Elevation of Cancer Antigen 15-3 (CA15-3) in Patients With Early Breast Cancer With Normal Serum CA15-3 Level.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC10139845/
    4. CA 15-3. Stanford Healthcare.  Available from:  https://stanfordhealthcare.org/medical-tests/t/tumor-markers/types/ca-15-3.html
    5. Qing H. Meng. Chapter 5 - Tumor markers. Self-Assessment Q&A in Clinical Laboratory Science.  Available from:  https://www.sciencedirect.com/science/article/abs/pii/B9780128220931000053.