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    What Is a CD 19, Flow Cytometry Test?

    The CD19 blood test measures the amount of CD19, a protein present on B cells' surfaces, which are important white blood cells involved in immune responses. CD19 plays a vital role in managing B cell functions, including their growth, division, and reaction to infections. This protein is found in both healthy B cells and certain cancers, especially those affecting B cells, like leukaemia and lymphoma.

    The CD19 blood test is primarily used to detect and monitor cancers related to B cells, including:

    • B-cell Acute Lymphoblastic Leukaemia (B-ALL): A cancer where abnormal B cells rapidly multiply.

    • Chronic Lymphocytic Leukaemia (CLL): A cancer that affects the blood and bone marrow, often in older adults.

    • B-cell Lymphomas: Cancers that affect the lymphatic system and involve B cells.

    Since CD19 is found on most B-cell tumours, this test can help locate abnormal B cells and determine whether the disease is progressing or metastasising. The levels of CD19 can vary between cancers: higher levels are observed in breast, liver, pancreatic, and adrenal cancers, while lower levels in cervical cancer and sarcoma may indicate poorer prognoses. Additionally, the CD19 Marker Flow Cytometry test may help predict the patient's response to treatment.

    Apart from cancer, CD19 may also be involved in other conditions like psoriasis and major depressive disorder (MDD) through immune signalling mechanisms.

    For those living in Gurgaon, a home-based CD19 test is available, with prompt sample collection and quick result delivery.

    CD 19, Flow Cytometry Test Parameters

    The CD19 test assesses the presence of CD19 protein on B cells in the bloodstream. CD19 is found on the surface of B cells and plays a vital role in allowing B cells to properly respond to infections. It collaborates with other proteins, such as the B cell receptor (BCR), to activate B cells when necessary, promoting their growth and the production of antibodies to fight infections.

    CD19 is present throughout B cell development, from its production in the bone marrow to its maturation in the spleen. It is essential for the normal function and progression of B cells. In addition to its immune function, CD19 is also found in several B-cell cancers, including leukaemia and lymphoma, which aids in diagnosis and treatment planning. Due to its specific presence in B cells, CD19 is also a target for certain treatments that harness the body's immune cells to attack cancer.

    CD 19, Flow Cytometry Test Preparation

    To prepare for the CD19 test at home, consider the following:

    • Prerequisites There are no specific prerequisites, such as fasting, required for the CD19 test.

    • Best Time to Get Tested You can schedule the CD19 test at any time during the day that works best for you.

    • Who Should Get a CD19 Test? It is recommended for individuals with frequent infections, suspected immune system issues, autoimmune disorders, or B cell cancers such as leukaemia and lymphoma, to monitor immune health and track disease progression.

    • Cautions Before Taking a CD19 Test No particular precautions are necessary before the CD19 test.

    Why Take the CD 19, Flow Cytometry Test?

    The CD19 test is important for detecting and tracking specific diseases, particularly those related to B cells. It is helpful for the following reasons:

    • Identifying Blood Cancers : Certain cancers, including acute lymphoblastic leukaemia (ALL), chronic lymphocytic leukaemia (CLL), and B-cell lymphomas, are associated with elevated CD19 levels. This test helps in the early identification of these conditions.

    • Distinguishing Lymphoma Variants : Different lymphoma types (a form of blood cancer) have varying CD19 levels. The test is useful for determining the specific type, which is key to selecting the right treatment.

    • Monitoring Cancer Development : For those undergoing treatment for blood cancers, the test helps assess whether the condition is improving or worsening over time.

    • Predicting Cancer Outcomes : Some cancers, such as cervical, rectal, and sarcoma cancers, show low CD19 levels when the disease has advanced. This test helps assess the severity of the disease.

    • Investigating Other Cancers : Elevated CD19 levels have been found in cancers like breast and liver cancer.

    The CD19 Marker Flow Cytometry test is crucial for diagnosing, monitoring, and researching various cancers by detecting B-cell changes, assessing disease progression, and identifying cancer types.

    FAQs on the CD 19, Flow Cytometry Test in Gurgaon

    The CD19 test in Gurgaon is priced at ₹2890. This amount covers rapid home sample collection within 60 minutes of booking. The results will be delivered within 108 hours following the sample collection.

    Yes, Orange Health Labs provides home sample collection for the CD19 test. Once you’ve booked, an experienced eMedic professional will come to your home within 60 minutes to collect the sample.

    The CD19 test helps assess B cell function and is useful in diagnosing immune system disorders, infections, and certain blood cancers, including lymphoma and leukaemia.

    No, fasting is not required prior to the CD19 test, meaning you can undergo the test without any special preparation.

    Booking a CD19 test with Orange Health Labs is easy—just follow these steps: • Search for the Test : Find the "CD19 test" and select Orange Health Labs from the available listings. • Confirm Your Booking : Provide your details, choose the correct location, and set a convenient time for sample collection. • Sample Collection : A certified eMedic will come to your location to collect the blood sample. • Analysis and Results : The sample will be tested in our NABL-accredited, ICMR-approved laboratory. Results will be sent to you via email or WhatsApp within 108 hours of sample collection.

    For the CD19 test, the normal range is 4.6–22.1% for the percentage of CD19 cells and 56.6–417.4 cells/µL for the absolute CD19 cell count.

    Test results are provided within 108 hours following the collection of the sample.

    How often you need the CD19 test depends on your specific health needs and the guidance of your doctor.

    The CD19 test assesses the percentage and absolute count of CD19 cells located on the surface of B cells circulating in your blood.

    The CD19 test is available in several areas across Gurgaon, including but not limited to Sector 14, Sector 15, Sector 21, Sector 22, Sector 23, Sector 24, Sector 29, Sector 31, Sector 40, Sector 42, Sector 43, Sector 45, Sector 46, Sector 50, Sector 51, Sector 52, Sector 53, Sector 54, Sector 55, Sector 56, DLF Phase 1, DLF Phase 2, DLF Phase 3, DLF Phase 4, and DLF Phase 5.

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    References

    1. Wang K, Wei G, Liu D. CD19: a biomarker for B cell development, lymphoma diagnosis and therapy. Experimental Hematology & Oncology.  Available from:  https://ehoonline.biomedcentral.com/articles/10.1186/2162-3619-1-36
    2. Zhou B, Wu T, Li H, Yang J, Ma Z, Ling Y, et al. Identification of CD19 as a shared biomarker via PPARγ/β-catenin/Wnt3a pathway linking psoriasis and major depressive disorder. Journal of Affective Disorders.  Available from:  https://www.sciencedirect.com/science/article/abs/pii/S0165032724013958
    3. CD19 - an overview | ScienceDirect Topics [Internet].  Available from:  https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/cd19