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    What is HLA-B27, Qualitative PCR Test?

    The HLA B27 Qualitative PCR Test is a specialised blood test that detects the presence of the HLA-B27 protein on white blood cells. While this protein is essential for immune function, its presence in some individuals is associated with a higher risk of developing autoimmune diseases. These disorders occur when the immune system mistakenly targets the body's own tissues.

    Autoimmune conditions linked to HLA-B27 include:

    • Ankylosing spondylitis – A chronic inflammatory condition affecting the spine, leading to pain and rigidity.

    • Reactive arthritis – Joint inflammation that occurs after an infection.

    • Juvenile arthritis – A joint disorder in children that causes persistent inflammation.

    A positive test result indicates the presence of HLA-B27 and an increased susceptibility to these conditions. However, it is not a definitive diagnosis, as many individuals with this protein never develop autoimmune diseases. Additional tests such as ESR, CRP, imaging scans (X-ray/MRI), and urine analysis may be necessary for accurate diagnosis.

    A negative result suggests a lower probability of these conditions. In transplant cases, mismatched HLA types can contribute to rejection of donated organs or tissues.

    For residents of Mumbai, home sample collection is available for the HLA B27 Qualitative PCR Test, ensuring convenience and timely reporting of results.

    HLA-B27, Qualitative PCR Test Parameters

    The HLA B27 Qualitative PCR Test identifies whether an individual carries the HLA-B27 antigen on white blood cells. This antigen belongs to the human leukocyte antigen (HLA) system, which is responsible for helping the immune system distinguish between the body's own cells and harmful pathogens like bacteria and viruses.

    HLA proteins are classified into Class I (A, B, C) and Class II (DR, DP, DQ) groups. While not as unique as fingerprints, these proteins vary among individuals and play a critical role in immune defence.

    The HLA-B27 antigen is inherited, meaning its presence is genetically determined. If a family member has an HLA-B27-associated condition, such as ankylosing spondylitis, the likelihood of developing a similar disorder increases for individuals who also assess positive.

    There are more than 15 subtypes of HLA-B27, with HLA-B2705 and HLA-B2702 being the most common. Some subtypes have been linked to an increased risk of autoimmune diseases, although research is ongoing. While a positive HLA-B27 test does not confirm the presence of a disease, it can provide valuable information for diagnosing autoimmune conditions.

    HLA-B27, Qualitative PCR Test Preparation

    If you need to take the HLA B27 Qualitative PCR test at home, here is what you should know:

    • Prerequisites : There are no dietary restrictions or special preparations needed before the test.

    • Best Time to Get Tested : This test can be scheduled at any time that suits you.

    • Who Should Get a HLA B27 Qualitative PCR Test? : This test is beneficial for individuals with persistent joint pain, swelling, stiffness, suspected autoimmune diseases, recurring uveitis (eye inflammation), or those needing tissue or organ transplant compatibility checks.

    • Cautions Before Taking an HLA B27 Qualitative PCR Test : No specific precautions are necessary before undergoing this test.

    Why Take the HLA-B27, Qualitative PCR Test?

    The HLA-B27 test helps identify potential autoimmune and inflammatory disorders. It may be recommended if you have:

    • Inflammation in the spine, chest, neck, joints, or eyes, often linked to conditions like ankylosing spondylitis or reactive arthritis.

    • Chronic joint pain, swelling, or stiffness, which might signal an autoimmune disease.

    • Frequent episodes of uveitis with no clear cause, suggesting a possible immune system involvement.

    This test is also useful for:

    • Evaluating the risk of autoimmune conditions associated with HLA-B27.

    • Assessing organ or bone marrow transplant compatibility to reduce rejection risks.

    Doctors often pair this test with other diagnostic tools, such as CCP antibody, CRP, ESR, rheumatoid factor, and X-rays, to provide a more complete assessment of inflammation and joint health.

    FAQs on HLA-B27, Qualitative PCR Test in Mumbai

    In Mumbai, the HLA B27 Qualitative PCR test is priced at ₹2500, covering home sample collection. A technician will visit within 60 minutes of booking, and your test results will be ready within 37 hours after collection.

    Yes, Orange Health Labs provides a home sample collection service for this test. After booking, a trained healthcare professional will arrive at your preferred location within 60 minutes to collect the sample safely and efficiently.

    This test helps determine the presence of the HLA-B27 antigen, which is linked to autoimmune conditions like ankylosing spondylitis, reactive arthritis, and psoriatic arthritis. It is also used in transplant evaluations to check for compatibility between a donor and recipient.

    No, fasting is not required for this test. You can schedule it at any convenient time without any dietary restrictions.

    You can easily book an HLA B27 Qualitative PCR test with Orange Health Labs by following these steps:

    • Find the Test: Search for "HLA B27 Qualitative PCR test", then choose Orange Health Labs from the options.

    • Schedule the Appointment: Enter your details, set your preferred location, and select a convenient time for sample collection.

    • Home Sample Collection: A trained eMedic professional will visit your home to collect the blood sample.

    • Testing & Report Delivery: The sample will be analysed at an NABL-accredited, ICMR-approved lab, and you will receive your test report via email or WhatsApp within 37 hours.

    The HLA B27 Qualitative PCR test results are classified as either positive or negative. A negative result is within the normal range and suggests a lower risk of HLA-B27-related autoimmune conditions. A positive result indicates the presence of the antigen, which may be associated with certain autoimmune diseases but is not a definitive diagnosis.

    Test reports are typically ready within 37 hours after sample collection.

    The frequency of testing varies based on your medical condition, symptoms, and doctor's advice. Your doctor will determine when repeat testing is necessary.

    This test detects a single parameter—the presence of the HLA-B27 antigen in your blood, which helps assess the risk of autoimmune diseases.

    You can take the HLA B27 Qualitative PCR test at various locations in Mumbai, including Colaba, Nariman Point, Marine Drive, Malabar Hill, Churchgate, Worli, Dadar, Parel, Byculla, Bandra, Andheri, Juhu, Ghatkopar, Powai, Chembur, Vashi, Belapur, Santacruz, Khar, Versova, Lokhandwala, Goregaon, Borivali, Kandivali, Mulund, Bhandup, Kurla.

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    References

    1. HLA-B27 antigen: MedlinePlus Medical Encyclopedia.  Available from:  https://medlineplus.gov/ency/article/003551.htm
    2. HLA-B27 Antigen.  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?ContentTypeID=167&ContentID=hla_b27_antigen
    3. Human leukocyte antigen (HLA) B27 | Pathology Tests Explained.  Available from:  https://www.pathologytestsexplained.org.au/ptests-pro.php?q=HLA+B27