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    What is CA 15.3, Breast Cancer Marker Test?

    The Cancer Antigen (CA) 15-3 test evaluates the concentration of CA 15-3 (a Cancer Antigen) within the bloodstream. This glycoprotein serves primarily as a tumour marker to track the status of breast cancer, particularly in monitoring therapy outcomes, identifying recurrences, and occasionally aiding in early detection. However, it is not suitable for initial diagnosis because of its limited specificity and sensitivity.

    Patients with advanced stages of breast cancer, who are advised to track disease progression, can opt for a CA 15-3 (Breast Cancer Marker) test performed conveniently at home.

    CA 15.3, Breast Cancer Marker Test Parameters

    The CA 15.3 (Breast Cancer Marker) test identifies levels of CA 15.3 protein in the blood.

    CA 15.3 is a protein generated by particular cell types, most notably breast cancer cells, and released into the bloodstream. It is predominantly utilised as a tumour marker for assessing breast cancer advancement and evaluating the effectiveness of treatment approaches.

    Increased levels of CA 15.3 are frequently connected to metastatic or advanced breast cancer. However, other reasons for elevated CA 15.3 include cancers such as lung, ovarian, or prostate cancers, along with benign issues like pelvic inflammatory disorders, benign ovarian or breast conditions, and liver diseases. Pregnancy, lactation, and inflammatory conditions like endometriosis may also elevate CA 15.3 levels.

    Test Limitations Are as Follows:

    Low Specificity

    While CA 15.3 is associated most strongly with breast cancer, its sensitivity and specificity are not very high, so other cancers or benign conditions can also elevate levels.

    Not Recommended for Screening

    This test is unsuitable for routine breast cancer screening and should not be used for initial diagnosis. It is mainly utilised for monitoring patients with confirmed cancer.

    Risk of False Negatives

    In certain cases, CA 15.3 levels might not rise despite the presence of cancer, especially during early or localized stages of the disease.

    CA 15.3, Breast Cancer Marker Test Preparation

    Follow these steps to get ready for the CA 15.3 (Breast Cancer Marker) test:

    • Prerequisites : There is no need to fast before undergoing a CA 15.3 (Breast Cancer Marker) test.

    • Best Time to Get Tested : The CA 15.3 (Breast Cancer Marker) test can be performed at any time that suits your schedule.

    • Who Should Get a CA 15.3 (Breast Cancer Marker) Test : Individuals undergoing treatment for metastatic or advanced breast cancer can consider this test to track the treatment’s progress. Additionally, people with a prior history of breast cancer might undergo this test to check for possible recurrence.

    • Cautions Before Taking a CA 15.3 (Breast Cancer Marker) Test : Share details of all current medications or health conditions with your doctor, as these may influence test outcomes. Be aware that conditions unrelated to cancer, such as benign breast diseases, pregnancy, or lactation, might also cause elevated CA 15.3 levels.

    Why Take the CA 15.3, Breast Cancer Marker Test?

    The CA 15.3 test plays an important role in managing breast cancer, especially in advanced or metastatic stages. Below are reasons to consider this test:

    • Track Breast Cancer Treatment: Repeated CA 15-3 measurements during or after therapy for breast cancer can help evaluate how effective the treatment is.

    • Identify Recurrence: Rising CA 15-3 levels in individuals with a prior breast cancer history may point to recurrence, though additional confirmation via biopsy or imaging is essential.

    • Prognostic Indicator: Research suggests that increased CA 15-3 levels at diagnosis or during treatment may correlate with a less favourable prognosis, but such data should be cautiously interpreted.

    • Monitor Metastatic Breast Cancer: This test is useful for tracking metastatic breast cancer progression when used alongside tests such as HER2 status or hormone receptor testing.

    • Aid in Diagnosing Metastases: The CA 15-3 test, combined with imaging and other tumor marker evaluations, can help in diagnosing breast cancer metastases cost-effectively.

    • Facilitate Treatment Decisions: It provides insights into disease progression, enabling doctors to make timely and necessary changes to treatment strategies.

    FAQs on CA 15.3, Breast Cancer Marker Test in Noida

    The CA 15.3 test is available in Noida at ₹1350. This fee covers a quick home sample collection within 60 minutes post-booking and test result delivery within 36 hours after collection.

    Yes, Orange Health Labs provides home sample collection for the CA 15.3 test. Our trained eMedic will collect your sample within 60 minutes of booking.

    The CA 15.3 test tracks breast cancer progression, measures treatment efficacy, and detects cancer recurrence, especially in cases of metastasis. It is not appropriate for early-stage screening or general breast cancer detection.

    Fasting is unnecessary for the CA 15.3 test. The test can be booked at any time of your preference.

    Follow these steps to book a CA 15.3 (Breast Cancer Marker) Test with Orange Health Labs, :

    Find the Test: Search for the "CA 15.3 (Breast Cancer Marker) Test" and select the Orange Health Labs option.

    Complete Your Booking: Provide your details, choose your preferred time and address for sample collection, and confirm the appointment.

    Sample Collection: A skilled eMedic will visit your home to collect the sample.

    Sample Processing: The sample will be tested at our ICMR-approved, NABL-accredited facility.

    Receive Results: Your results will be shared through WhatsApp or email within 36 hours of collection.

    The normal reference values for the CA 15.3 test usually fall below 35 U/mL. Higher levels may suggest breast cancer recurrence or progression. It is crucial to consult your physician for detailed result evaluation.

    Test results for the CA 15.3 test are generally processed and delivered within 36 hours of sample collection.

    The frequency of testing depends on your doctor's advice and clinical need. Regular testing may be recommended to monitor ongoing treatment outcomes.

    The CA 15.3 (Breast Cancer Marker) test evaluates one key parameter: the concentration of cancer antigen 15-3, which is closely linked to advanced breast cancer.

    Orange Health provides convenient home sample collection services for CA 15.3 testing in various Noida localities, including but not limited to Sector 1, Sector 15, Sector 18, Sector 26, Sector 37, Sector 50, Sector 62, Sector 76, Sector 93, Sector 100, Sector 104, Sector 110, Sector 120, Sector 128, Sector 137, Sector 150, Sector 168, Sector 71, Sector 63, Sector 22, Sector 41, Sector 108, Sector 47, Sector 121, Sector 45.

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    References

    1. CA 15-3. 2024  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=167&contentid=ca_15_3
    2. Cancer antigen 15-3 (CA15-3) test [Internet]. Canadian Cancer Society.  Available from:  https://cancer.ca/en/treatments/tests-and-procedures/cancer-antigen-15-3-ca-15-3
    3. Prognostic Impact of Elevation of Cancer Antigen 15-3 (CA15-3) in Patients With Early Breast Cancer With Normal Serum CA15-3 Level.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC10139845/
    4. CA 15-3. Stanford Healthcare.  Available from:  https://stanfordhealthcare.org/medical-tests/t/tumor-markers/types/ca-15-3.html
    5. Qing H. Meng. Chapter 5 - Tumor markers. Self-Assessment Q&A in Clinical Laboratory Science.  Available from:  https://www.sciencedirect.com/science/article/abs/pii/B9780128220931000053.