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    What is Complement 4 (C4) Level Test?

    The Complement 4 (C4) test is a blood test used to measure the levels of C4 protein in your bloodstream. This protein is an integral part of the complement system, a group of nine interconnected proteins (C1 through C9) that play an essential role in strengthening your immune defenses by attacking harmful pathogens such as viruses and bacteria. The C4 test is used to evaluate immune health and identify certain health conditions. Low levels of C4 may suggest that the immune system is erroneously attacking healthy tissues, a characteristic feature of autoimmune diseases like lupus. Reduced levels of C4 could also indicate chronic infections, blood-related disorders that cause the breakdown of red blood cells, liver dysfunction, malnutrition, or severe episodes of swelling beneath the skin. Conversely, elevated levels of C4 might signify recovery from an illness, a positive response to treatment, or the presence of health conditions such as lung or digestive disorders and, occasionally, cancers.

    To obtain a more comprehensive evaluation of your immune health, additional medical tests may be recommended.

    For residents of Noida, the Complement 4 (C4) test at home, ensures reliable home sample collection services and prompt delivery of accurate reports.

    Complement 4 (C4) Level Test Parameters

    The Complement 4 (C4) test evaluated one key parameter:

    • The concentration of C4 protein in your blood.

    Complement proteins are vital components of your immune defense system. They work in harmony to protect your body from harmful microorganisms, including viruses and bacteria. Once a threat is detected, these proteins activate the immune response and construct a protective structure called the Membrane Attack Complex (MAC). The MAC targets the harmful cells, puncturing their outer membrane and breaking them down completely.

    In addition to destroying pathogens, the complement system plays a significant role in amplifying the immune response. It increases blood vessel permeability, facilitating white blood cells' movement from the bloodstream into the infected tissues. The system also attracts additional white blood cells to the infection site and enhances phagocytosis, a process where immune cells like macrophages and neutrophils engulf and eliminate harmful microorganisms. Furthermore, complement proteins help clear immune complexes from circulation, ensuring the immune system operates at its best.

    C3 and C4 are the two most frequently analysed complement proteins, as they perform central roles in immune processes. Specifically, C4 is essential for identifying and neutralizing harmful pathogens like bacteria and viruses, making it a cornerstone of the body’s defense mechanisms.

    If immune dysfunction is suspected, both C3 and C4 levels are measured to assess immune health. If abnormalities are identified, further analysis may include other complement proteins, such as C1 inhibitors, to identify the cause. Tests to measure overall complement activity can also help determine whether certain proteins in the system are missing or malfunctioning.

    Complement 4 (C4) Level Test Preparation

    Here’s a comprehensive guide to ensure you’re prepared for the Complement 4 (C4) test:

    Prerequisites: You don’t need to fast before the Complement 4 (C4) test.

    Best Time to Get Tested: The Complement 4 (C4) test has no specific time constraints. You can conveniently schedule and complete the test based on your personal availability and preferences.

    Who Should Get a C4 Test: This test is recommended for people suspected of having autoimmune diseases like systemic lupus erythematosus (SLE) or chronic kidney issues. It’s also suitable for those diagnosed with long-term conditions like chronic hepatitis or for monitoring the effectiveness of autoimmune treatment plans.

    Cautions Before Taking C4 Test: No additional preparation or cautionary steps are required for this test.

    Why Take the Complement 4 (C4) Level Test?

    If you’re dealing with symptoms that might identify to an autoimmune condition like lupus or rheumatoid arthritis (RA), a Complement 4 (C4) test maybe recommended. Here’s what to look for:

    • Mild fevers that stick around without a clear reason.

    • Headaches or dizziness that seem to happen more often than usual.

    • Joints that feel stiff, swollen, or painful, making everyday activities difficult.

    • A unique butterfly-shaped rash appearing on your face.

    • Sunlight causing unusual skin reactions or discomfort.

    • Mouth sores or ulcers that won’t go away or keep coming back.

    • Swelling, especially around your eyes, hands, or feet.

    • Constant fatigue or tiredness that just doesn’t seem to improve.

    • Hair loss or thinning that happens suddenly or without an obvious cause.

    • Chest pain, particularly when breathing deeply.

    • Fingers or toes that change colour in cold weather or stressful situations.

    This test also comes in handy if you’re prone to recurring bacterial or fungal infections, as it assesses how strong your immune system is. Additionally, it can help detect kidney problems or chronic hepatitis. For those with autoimmune diseases, the Complement 4 (C4) test is vital for monitoring how the disease is progressing and checking whether current treatments are working.

    FAQs on Complement 4 (C4) Level Test in Noida

    The price for the Complement 4 (C4) test in Noida is ₹895. This includes hassle-free home sample collection, which will be completed within 60 minutes after confirming your booking.

    Yes, Orange Health Labs offers home sample collection for the Complement 4 (C4) test in Noida. A certified eMedic will visit your location within 60 minutes of booking your test, depending on slot availability.

    The Complement 4 (C4) test aids in diagnosing autoimmune disorders, evaluating immune system health, and monitoring conditions such as lupus and rheumatoid arthritis to ensure better management.

    Fasting is not necessary unless your doctor recommends it. Always consult your doctor to confirm any special instructions.

    Booking the Complement 4 (C4) test at Orange Health Labs in Noida is simple:

    • Search the test: Visit the Orange Health website or app to find the C4 test.

    • Confirm your booking: Enter your details, choose a time slot, and complete the appointment.

    • Sample collection: A trained eMedic will collect your blood sample from your chosen address at the scheduled time.

    • Laboratory processing: The sample is processed in an ICMR-approved, NABL-certified laboratory for accurate analysis.

    • Report delivery: Test reports are sent via email, WhatsApp, and the Orange Health app within 72 hours.

    Normal C4 levels are between 10 and 40 mg/dL. However, this range might slightly vary depending on the laboratory’s specific testing standards.

    After you confirm the booking, an eMedic will collect your blood sample within 60 minutes at your chosen location. The test report will be delivered within 72 hours post sample processing.

    The frequency of taking the C4 test depends on your health condition and your doctor’s recommendation for monitoring autoimmune diseases or other related concerns.

    The C4 test evaluates one critical parameter: the concentration of C4 complement protein in the bloodstream, which plays an essential role in immune system function.

    Orange Health Labs ensures doorstep blood sample collection for the C4 test across major regions in Noida, such as Sector 1, Sector 15, Sector 18, Sector 26, Sector 37, Sector 50, Sector 62, Sector 76, Sector 93, Sector 100, Sector 104, Sector 110, Sector 120, Sector 128, Sector 137, Sector 150, Sector 168, Sector 71, Sector 63, Sector 22, Sector 41, Sector 108, Sector 47, Sector 121, Sector 45.

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    References

    1. Clinic C. C4 Complement Blood Test.  Available from:  https://my.clevelandclinic.org/health/diagnostics/c4-complement-blood-test
    2. Complement C4 (Blood).  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=167&contentid=complement_c4_blood
    3. Complement | Pathology Tests Explained.  Available from:  https://www.pathologytestsexplained.org.au/ptests-pro.php?q=Complement#more-information
    4. Wang H, Liu M. Complement C4, Infections, and Autoimmune Diseases. Frontiers in Immunology.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC8317844/