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    What is Complement 4 (C4) Level Test?

    The Complement 4 (C4) test is a blood test that assesses the amount of C4 protein present in your bloodstream. This protein plays a crucial role in the complement system, a complex network of nine primary proteins (C1 through C9) that work collectively to strengthen your body’s immune defenses by targeting harmful bacteria and viruses. The C4 test is recommended to understand your immune system’s condition and diagnose specific medical concerns. A significant drop in C4 levels might indicate that the immune system is mistakenly targeting healthy tissues, which is characteristic of autoimmune disorders such as lupus. Low C4 levels can also result from chronic infections, blood conditions involving excessive breakdown of red blood cells, liver issues, malnutrition, or sudden episodes of severe swelling under the skin. Elevated levels of C4 might indicate that the body is recovering well from an illness, responding positively to treatment, or managing conditions like lung and digestive disorders, and, in rare instances, cancers.

    To gain more detailed information into your immune system’s functionality, additional tests may also be suggested.

    If you live in Gurgaon, you can easily schedule the Complement 4 (C4) test at home and take advantage of their convenient home sample collection service, ensuring accurate and timely results.

    Complement 4 (C4) Level Test Parameters

    The Complement 4 (C4) test focuses on one crucial parameter:

    • Levels of C4 complement protein in the bloodstream.

    Complement proteins are an essential part of your immune system, working together to protect your body against harmful pathogens, including bacteria and viruses. Upon identifying a threat, these proteins activate a defense mechanism and assemble into a structure known as the Membrane Attack Complex (MAC). This complex binds to the outer layer of harmful cells, punctures their membrane, and causes them to break apart.

    Beyond eliminating pathogens, the complement system amplifies the immune response through multiple pathways. It increases the permeability of blood vessels, enabling white blood cells to exit the circulatory system and reach the affected tissues more effectively. Additionally, it recruits more immune cells to infection sites and enhances phagocytosis, where specialised cells like neutrophils and macrophages engulf and destroy harmful microorganisms. Complement proteins also help remove immune complexes from the bloodstream, maintaining the efficiency of the immune system.

    Among the complement proteins, C3 and C4 are the most commonly evaluated because they play a pivotal role in the body’s immune response. Specifically, C4 is crucial for identifying and neutralizing harmful pathogens, making it indispensable for combating infections.

    When an immune dysfunction is suspected, both C3 and C4 levels are measured. If abnormalities are found, additional tests may include analysing other complement proteins, such as C1 inhibitors, to identify specific issues. Evaluating overall complement activity can also provide valuable information, especially when a protein in the system is missing or not functioning properly.

    Complement 4 (C4) Level Test Preparation

    Here’s everything you need to know about preparing for the Complement 4 (C4) test:

    Prerequisites: Fasting is not necessary before undergoing the Complement 4 (C4) blood test.

    Best Time to Get Tested: There are no specific timing requirements for this test. You can schedule and complete it based entirely on your convenience and preferred availability.

    Who Should Get a C4 Test: The Complement 4 (C4) test is highly recommended for individuals experiencing symptoms of autoimmune disorders, such as lupus or rheumatoid arthritis, as well as for those dealing with chronic conditions like kidney disease or hepatitis. It is also useful for people who need to track the progression of autoimmune diseases or assess how well treatments are working.

    Cautions Before Taking C4 Test: This test does not require any particular precautions or additional measures.

    Why Take the Complement 4 (C4) Level Test?

    The Complement 4 (C4) test is often suggested for people experiencing symptoms that might indicate autoimmune conditions like lupus or rheumatoid arthritis (RA). Here are some signs to watch out for:

    • Ongoing mild fever that doesn’t seem to have a clear cause.

    • Dizziness or frequent headaches that leave you feeling off balance.

    • Painful, swollen, or stiff joints that make it hard to move comfortably.

    • A butterfly-shaped rash on the face, particularly across the cheeks.

    • Being unusually sensitive to sunlight, which may cause rashes or skin irritation.

    • Mouth sores that keep coming back or don’t heal easily.

    • Puffiness or swelling around the eyes, hands, or feet.

    • Feeling constantly drained of energy, even after getting plenty of rest.

    • Hair falling out suddenly or thinning more than usual.

    • Chest pain, especially noticeable when taking deep breaths.

    • Fingers and toes turning pale, blue, or red, especially in the cold or when stressed.

    This test is also helpful if you’ve been dealing with frequent bacterial or fungal infections, as it evaluates how well your immune system is functioning. It can also be used to detect kidney-related issues or chronic hepatitis. If you’re managing an autoimmune disease, the Complement 4 (C4) test is key for keeping track of how your condition is progressing and checking if your treatment is working effectively.

    FAQs on Complement 4 (C4) Level Test in Gurgaon

    The Complement 4 (C4) test in Gurgaon is priced at ₹895. The cost covers smooth home sample collection, completed within 60 minutes of confirming your appointment.

    Yes, Orange Health Labs provides home sample collection for the Complement 4 (C4) test in Gurgaon. A trained eMedic will visit your home within 60 minutes of booking, based on availability.

    The Complement 4 (C4) test is primarily used for diagnosing autoimmune conditions, assessing immune system performance, and tracking diseases like lupus and rheumatoid arthritis for effective management.

    Fasting is generally not required for this test unless specified by your doctor. Follow your physician’s guidance to prepare for the test.

    To schedule the Complement 4 (C4) test in Gurgaon:

    • Find the test: Look for the Complement 4 (C4) test on the Orange Health app or website.

    • Finalize your booking: Enter the necessary details, pick a time slot, and complete the appointment.

    • Blood sample collection: A qualified eMedic will visit your address to collect the blood sample at the scheduled time.

    • Laboratory testing: The sample will be analyzed in NABL-accredited, ICMR-approved laboratory for analysis.

    • Get your report: The results will be shared via WhatsApp, email, and the Orange Health app within 80 hours.

    The normal range for Complement 4 levels lies between 10 and 40 mg/dL. These values can differ slightly depending on the laboratory.

    Once you confirm your booking, an eMedic will collect your blood sample within 60 minutes from your preferred location. The report will be available within 80 hours after the sample is processed.

    The need to repeat the Complement 4 (C4) test varies depending on your medical condition and your doctor’s instructions for monitoring autoimmune disorders or other health issues.

    This test measures a single parameter: the level of C4 complement protein in your blood, a key component of your immune defense system.

    Orange Health Labs offers convenient doorstep sample collection for the Complement 4 test in areas such as DLF Phase 1, DLF Phase 2, DLF Phase 3, DLF Phase 4, DLF Phase 5, Sector 14, Sector 15, Sector 21, Sector 22, Sector 23, Sector 24, Sector 29, Sector 31, Sector 40, Sector 42, Sector 43, Sector 45, Sector 46, Sector 50, Sector 51, Sector 52, Sector 53, Sector 54, Sector 55, Sector 56.

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    References

    1. Clinic C. C4 Complement Blood Test.  Available from:  https://my.clevelandclinic.org/health/diagnostics/c4-complement-blood-test
    2. Complement C4 (Blood).  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=167&contentid=complement_c4_blood
    3. Complement | Pathology Tests Explained.  Available from:  https://www.pathologytestsexplained.org.au/ptests-pro.php?q=Complement#more-information
    4. Wang H, Liu M. Complement C4, Infections, and Autoimmune Diseases. Frontiers in Immunology.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC8317844/