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    What Is a CD 19, Flow Cytometry Test?

    The CD19 blood test measures the level of CD19, a protein that resides on the surface of B cells, a type of white blood cell involved in immune function. CD19 is integral in regulating B cell activity, supporting their growth, division, and immune responses. It is present in normal B cells as well as in certain types of cancer, particularly those involving B cells, such as leukaemia and lymphoma.

    The main purpose of the CD19 blood test is to detect and monitor cancers that involve B cells, such as:

    • B-cell Acute Lymphoblastic Leukaemia (B-ALL): A cancer characterised by the uncontrolled proliferation of abnormal B cells.

    • Chronic Lymphocytic Leukaemia (CLL): A cancer affecting the blood and bone marrow, more common in the elderly.

    • B-cell Lymphomas: Cancers that affect the lymphatic system and involve B cells.

    As CD19 is present on the surface of the majority of B-cell tumours, this test helps locate abnormal B cells and track disease progression or metastasis. CD19 levels vary between cancers: higher levels are found in breast, liver, pancreatic, and adrenal cancers, while lower levels are associated with cervical cancer and sarcoma, which may result in worse outcomes. The CD19 Marker Flow Cytometry test can also offer insights into how well a patient will respond to treatment. CD19 has also been linked to other conditions like psoriasis and major depressive disorder (MDD), through immune signalling pathways.

    For residents in Hyderabad, a CD19 test can be conducted at home with prompt sample collection and fast result delivery.

    CD 19, Flow Cytometry Test Parameters

    The CD19 test focuses on a single parameter: the presence of CD19 protein on B cells in the bloodstream. CD19 is a protein located on the surface of B cells, playing a vital role in helping B cells correctly respond to infections. It works with other proteins, like the B cell receptor (BCR), to activate B cells when required, which promotes their growth and the production of antibodies to fight infections.

    CD19 is present throughout B cell development, from the bone marrow, where B cells are created, to the spleen, where they mature. It is essential for the normal function and progression of B cells. Apart from its immune functions, CD19 is also found in numerous B-cell cancers, such as leukaemia and lymphoma, aiding both in diagnosis and treatment planning. Since CD19 is specific to B cells, it is targeted by certain therapies that employ the body’s immune cells to fight cancer.

    CD 19, Flow Cytometry Test Preparation

    To get ready for your CD19 test at home, keep the following in mind:

    • Prerequisites No specific prerequisites, such as fasting, are required for the CD19 test.

    • Best Time to Get Tested The CD19 test can be scheduled for any time during the day that is most convenient for you.

    • Who Should Get a CD19 Test? This test is recommended for those with frequent infections, suspected immune system disorders, autoimmune conditions, or B cell cancers like leukaemia and lymphoma, to assess immune health and monitor disease progression.

    • Cautions Before Taking a CD19 Test There are no specific precautions to take before the CD19 test.

    Why Take the CD 19, Flow Cytometry Test?

    The CD19 test is essential for identifying and monitoring specific diseases, particularly those that affect B cells. It is useful for:

    • Identifying Blood Cancers : Cancers such as acute lymphoblastic leukaemia (ALL), chronic lymphocytic leukaemia (CLL), and B-cell lymphomas are associated with high levels of CD19. This test assists in early detection of these cancers.

    • Differentiating Lymphoma Types : Different lymphoma types (a form of blood cancer) exhibit varying CD19 levels. The test helps pinpoint the exact type, which is vital for selecting the appropriate treatment.

    • Monitoring Cancer Development : For those receiving treatment for blood cancers, this test helps assess whether the disease is improving or worsening.

    • Predicting Cancer Outcomes : Certain cancers, including cervical, rectal, and sarcoma cancers, tend to have lower CD19 levels when the disease has progressed, helping determine its severity.

    • Investigating Other Cancers : Increased CD19 levels have been found in cancers like breast cancer and liver cancer.

    The CD19 Marker Flow Cytometry test plays a crucial role in diagnosing, monitoring, and researching various cancers by detecting changes in B cells, tracking disease progression, and identifying different types of cancer.

    FAQs on the CD 19, Flow Cytometry Test in Hyderabad

    The CD19 test in Hyderabad costs ₹2890. This charge includes quick home sample collection, which will be completed within 60 minutes of booking. You will receive the results within 108 hours after the sample is collected.

    Yes, home sample collection for the CD19 test is available through Orange Health Labs. After you make your booking, a professional eMedic will come to your home within 60 minutes to collect the sample.

    Top of Form

    Bottom of Form 3. What is a CD19 test used for?

    The CD19 test is used to evaluate the function of B cells, assisting in the diagnosis of immune system issues, infections, and certain blood cancers, including lymphoma and leukaemia.

    No, fasting is not needed before the CD19 test, so you can take the test without any special arrangements.

    Booking a CD19 test with Orange Health Labs is straightforward—just follow these steps:

    • Search for the Test : Find the "CD19 test" and choose the Orange Health Labs option from the list.

    • Confirm Your Booking : Enter your personal details, select your location, and pick a time for sample collection that suits you.

    • Sample Collection : A qualified eMedic will visit your location to collect the sample.

    • Analysis and Results : The sample will be tested at our NABL-accredited, ICMR-approved laboratory. Results will be sent to you via email or WhatsApp within 108 hours after the sample is collected.

    The normal values for CD19 test results are 4.6–22.1% for the percentage of CD19 cells, and 56.6–417.4 cells/µL for the absolute count of CD19 cells.

    Test results are typically ready within 108 hours after the sample is collected.

    How frequently the CD19 test is performed will depend on your health condition and the recommendations of your doctor.

    The CD19 test measures the percentage and absolute count of CD19 cells on B cells in your bloodstream.

    The CD19 test is available in several areas across Hyderabad, including but not limited Banjara Hills, Jubilee Hills, Gachibowli, Madhapur, Tarnaka, Abids, Koti, Mehdipatnam, Dilsukhnagar, Uppal, LB Nagar, fNallagandla, Nizampet, Attapur, Hitech City, Kondapur, Begumpet, Somajiguda, Ameerpet, Panjagutta, Kukatpally, Miyapur, Manikonda, Secunderabad, and Malkajgiri.

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    References

    1. Wang K, Wei G, Liu D. CD19: a biomarker for B cell development, lymphoma diagnosis and therapy. Experimental Hematology & Oncology.  Available from:  https://ehoonline.biomedcentral.com/articles/10.1186/2162-3619-1-36
    2. Zhou B, Wu T, Li H, Yang J, Ma Z, Ling Y, et al. Identification of CD19 as a shared biomarker via PPARγ/β-catenin/Wnt3a pathway linking psoriasis and major depressive disorder. Journal of Affective Disorders.  Available from:  https://www.sciencedirect.com/science/article/abs/pii/S0165032724013958
    3. CD19 - an overview | ScienceDirect Topics [Internet].  Available from:  https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/cd19