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    What Is the Acetyl Choline Receptor Binding antibody Test?

    The Acetylcholine Receptor (AChR) Antibody test is a blood examination that detects antibodies targeting acetylcholine receptors, which are crucial for nerve-muscle communication. Acetylcholine, a neurotransmitter, binds to muscle receptors, triggering contractions. In myasthenia gravis (MG), an autoimmune disease, abnormal antibodies are produced against AChR, impairing this process and leading to muscle weakness and fatigue.

    This test is instrumental in diagnosing neuromuscular disorders that involve acetylcholine dysfunction. It is especially helpful when clinical signs such as ptosis (drooping eyelids), muscle weakness, difficulty speaking, or breathing problems raise concerns about MG but further diagnostic confirmation is necessary. The test can also be used to monitor therapeutic responses in conditions like thymoma and MG, as successful treatment often results in lower antibody levels.

    For convenience, individuals in Mumbai can easily arrange for the Acetylcholine Receptor Antibody test at home.

    Acetyl Choline Receptor Binding antibody Test Parameters

    The AChR antibody test quantifies autoantibodies in the blood that target acetylcholine receptors.

    Acetylcholine is crucial for muscle contractions, but in myasthenia gravis (MG), the body produces antibodies against the AChR protein, which impedes acetylcholine's function. AChR antibodies affect the nerve components responsible for sending signals to muscles. These antibodies interfere with neuromuscular communication by blocking, altering, or destroying acetylcholine receptors at the neuromuscular junction. In most generalized cases, they are present in 85-90% of patients.

    Acetyl Choline Receptor Binding antibody Test Preparation

    Getting ready for the AChR antibody test is straightforward. Here's how to prepare:

    • Prerequisites: Fasting is not necessary before taking the test.

    • Best Time to Get Tested: You can have the test done at any time during the day.

    • Who Should Get an Acetylcholine Receptor Antibody Test?: Anyone experiencing signs of myasthenia gravis, such as weakness in the muscles, drooping eyelids, trouble swallowing, or difficulty with speech, should undergo this test. It is also recommended for people with suspected autoimmune neuromuscular disorders or thymoma.

    • Cautions Before Taking an Acetylcholine Receptor Antibody Test: Certain medications, such as anaesthetics and muscle relaxants, might alter the results. It’s important to discuss any medications you’re taking with your doctor beforehand.

    Why Take the Acetyl Choline Receptor Binding antibody Test?

    Diagnosing Myasthenia Gravis (MG), an autoimmune disorder affecting the neuromuscular system, often relies on the AChR Antibody test. Early diagnosis is essential for symptom control and improving life quality. This test may be suggested when symptoms like the following emerge:

    Muscle weakness in limbs, neck, and fingers

    Eyelid drooping (ptosis)

    Difficulty speaking

    Trouble swallowing or chewing

    Breathing difficulties

    Unstable gait

    FAQs on Acetyl Choline Receptor Binding antibody Test in Mumbai

    The Acetylcholine Receptor (AChR) Antibody test cost in Mumbai is ₹3630. This includes home sample collection within 60 minutes of booking, and test results available within 132 hours after sample collection.

    Yes, complementary home sample collection for the AChR Antibody test is available with Orange Health Labs. A trained eMedic will visit your chosen location to collect the sample within 60 minutes of booking.

    The main use of Acetylcholine Receptor Antibody test is to diagnose myasthenia gravis. This is by detecting the presence of antibodies in blood that interfere with neuromuscular communication. It helps in treatment monitoring and also diagnose other conditions like thymoma.

    No, fasting is not required for the Acetylcholine Receptor Antibody test.

    You can follow these steps to book your test with Orange Health Labs:

    • Locate the Test: Look for the "Acetylcholine Receptor Antibody test" and select Orange Health Labs.

    • Confirm the Appointment: Enter your details, choose your location, and select a convenient time for sample collection.

    • Sample Collection: A trained eMedic will collect the sample from your chosen location.

    • Laboratory Testing: The sample will be analysed at an NABL-accredited, ICMR-approved laboratory.

    • Results: You will receive your results via email or WhatsApp within 132 hours.

    Acetylcholine Receptor Antibody concentrations are usually under 0.05nmol/L. Levels that are low or undetectable are typically normal, whereas elevated levels could indicate myasthenia gravis or other disorders affecting the neuromuscular system. Your doctor will provide an interpretation of these findings, considering both your symptoms and medical history.

    The test results are available within about 132 hours of sample collection.

    How often you undergo testing depends on your doctor's advice. Typically, this test is ordered when myasthenia gravis is suspected or for monitoring how the condition is developing and how you’re responding to treatment. Your physician will decide if further tests are required based on your health condition.

    This test measures the levels of acetylcholine receptor antibodies in the blood. These play a role in blocking the acetylcholine receptors at the neuromuscular junction.

    With Orange Health Labs, you can conveniently undergo the Acetylcholine Receptor Antibody test in the comfort of your home or office. You can request sample collection service at various localities in Mumbai, including Colaba, Nariman Point, Marine Drive, Malabar Hill, Churchgate, Worli, Dadar, Parel, Byculla, Bandra, Andheri, Juhu, Ghatkopar, Powai, Chembur, Vashi, Belapur, Santacruz, Khar, Versova, Lokhandwala, Goregaon, Borivali, Kandivali, Mulund, Bhandup, Kurla.

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    References

    1. Acetylcholine Receptor Antibody (Blood) - Health Encyclopedia - University of Rochester Medical Center.  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=167&contentid=acetylcholine_receptor_antibody_blood
    2. Acetylcholine receptor antibody: MedlinePlus Medical Encyclopedia.  Available from:  https://medlineplus.gov/ency/article/003576.htm
    3. Acetylcholine Receptor Antibody.  Available from:  https://www.ucsfhealth.org/medical-tests/acetylcholine-receptor-antibody
    4. Journal of Neurology Neurosurgery & Psychiatr.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC490626/
    5. ‌Acetylcholine receptor antibody Information | Mount Sinai - New York.  Available from:  https://www.mountsinai.org/health-library/tests/acetylcholine-receptor-antibody