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    Anti Smooth Muscle antibody (Anti-SMA) (IFA)2626200024% off
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    What is Anti Smooth Muscle antibody (Anti-SMA) (IFA) Test?

    The Anti Smooth Muscle Antibody (ASMA) test is a laboratory test that detects smooth muscle antibodies (SMAs) in the blood. These autoantibodies mistakenly attack liver cells, leading to inflammation and damage. The test is primarily used to diagnose autoimmune hepatitis (AIH), a chronic liver disorder in which the immune system wrongly targets the liver, potentially causing long-term harm.

    The immune system is responsible for defending against infections and foreign invaders. However, in conditions like AIH, it malfunctions and produces autoantibodies, such as ASMAs, that damage the body’s tissues. If untreated, AIH can progress to cirrhosis, a serious complication. To manage AIH, doctors often prescribe immunosuppressive medications to reduce immune system activity and slow liver damage.

    AIH is categorized into two types:

    • Type 1 AIH, the most common form, affects children and adults, especially women.

    • Type 2 AIH, a rarer form, primarily seen in girls, is associated with additional antibodies such as LKM-1.

    Doctors typically order an ASMA test alongside other autoantibody tests, including ANA and LKM-1, to confirm the diagnosis.

    If you're based in Mumbai, you can avail of home sample collection for this test, ensuring an easy and efficient process with quick results.

    Anti Smooth Muscle antibody (Anti-SMA) (IFA) Test Parameters

    The Anti-Smooth Muscle Antibody (ASMA) test measures the presence of antibodies that attack smooth muscle proteins in the bloodstream. These proteins are found in the walls of hollow organs like the intestines, stomach, and blood vessels, but they are also present in large quantities in liver cells. High ASMA levels are often a sign of autoimmune hepatitis (AIH) or other liver-related conditions.

    By detecting whether the immune system is erroneously attacking the liver, this test plays a key role in diagnosing AIH. To ensure a comprehensive diagnosis, doctors frequently recommend it alongside ANA and LKM-1 tests.

    Several techniques are used to analyse ASMA levels, helping to pinpoint specific antibody types and their concentration, offering a clearer picture of liver disease. ASMA was first identified in individuals with liver disorders, and its discovery has since been vital in the early detection and management of AIH. Prompt diagnosis through this test can help prevent serious liver damage, cirrhosis, and failure. If ASMA is present, treatment aims to control immune activity to minimize further liver harm.

    Anti Smooth Muscle antibody (Anti-SMA) (IFA) Test Preparation

    Getting Ready for the Anti-Smooth Muscle Antibody (ASMA) Test is convenient with these steps:

    • Prerequisites :

    You don’t need to fast or follow any special instructions before the test.

    • Best Time to Get Tested :

    The test can be done at any time during the day.

    • Who Should Get an Anti Smooth Muscle Antibody Test? :

    It is recommended for people with liver-related symptoms (such as jaundice, persistent tiredness, and abdominal pain) or those with abnormal liver test results to check for autoimmune hepatitis.

    • Cautions Before Taking an Anti Smooth Muscle Antibody Test :

    There are no specific precautions to follow before the test.

    Why Take the Anti Smooth Muscle antibody (Anti-SMA) (IFA) Test?

    The Anti-Smooth Muscle Antibody (ASMA) test helps detect autoimmune hepatitis (AIH), particularly in people experiencing:

    • Yellowish skin and eyes (jaundice)

    • Chronic tiredness and weakness

    • Loss of appetite or frequent nausea

    • Abdominal discomfort or pain

    • Unusual joint pain or stiffness

    • Dark-coloured urine and pale stools

    • Skin problems, including acne, rashes, vitiligo, or psoriasis

    Since AIH can develop without clear symptoms, routine blood tests like a Comprehensive Metabolic Panel (CMP) may detect early signs of liver dysfunction, making an ASMA test necessary. If antibodies are found, further testing, including a liver biopsy, may be required to assess the level of liver damage.

    FAQs on Anti Smooth Muscle antibody (Anti-SMA) (IFA) Test in Mumbai

    The cost of the test in Mumbai is ₹2000. This includes home sample collection, which is done within 60 minutes of booking. Test reports are delivered within 99 hours after collection.

    Yes, Orange Health Labs offers home sample collection services for the Anti-Smooth Muscle Antibody test. Once you book, a medical professional will visit within 60 minutes to collect your sample.

    This test plays a crucial role in diagnosing autoimmune hepatitis (AIH) by detecting antibodies that target liver cells. It also helps doctors evaluate liver health and decide if further investigations, like a liver biopsy, are needed.

    No, fasting is not necessary. The test can be taken at any time of the day.

    To schedule an Anti-Smooth Muscle Antibody test with Orange Health Labs in Mumbai:

    • Look up the test: Search for "Anti-Smooth Muscle Antibody test" and select Orange Health Labs.

    • Book your slot: Enter your details, and location, and choose a time for sample collection.

    • Get your sample collected: A trained eMedic professional will come to your home for sample collection.

    • Receive your results: The sample will be tested at a NABL-certified, ICMR-approved lab, and reports will be shared within 99 hours via email or WhatsApp.

    A negative test result is considered normal, as it means no antibodies were found. A positive result may indicate an autoimmune liver disorder, such as autoimmune hepatitis.

    Your results will be provided within 99 hours after your blood sample is collected.

    The requirement for repeat testing is based on your health condition and the doctor’s advice.

    This test identifies autoantibodies against smooth muscle, which may be linked to liver autoimmune diseases.

    You can get the test done in several localities of Mumbai including but not limited to Colaba, Nariman Point, Marine Drive, Malabar Hill, Churchgate, Worli, Dadar, Parel, Byculla, Bandra, Andheri, Juhu, Ghatkopar, Powai, Chembur, Vashi, Belapur, Santacruz, Khar, Versova, Lokhandwala, Goregaon, Borivali, Kandivali, Mulund, Bhandup, Kurla.

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    References

    1. Smooth Muscle Antibody (SMA) Test: MedlinePlus Medical Test. 2. Anti-smooth muscle antibody - UF Health.  Available from:  https://medlineplus.gov/lab-tests/smooth-muscle-antibody-sma-test/
    2. Zhang WC, Zhao FR, Chen J, Chen WX. Meta-Analysis: Diagnostic Accuracy of Antinuclear Antibodies, Smooth Muscle Antibodies and Antibodies to a Soluble Liver Antigen/Liver Pancreas in Autoimmune Hepatitis.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC3961308/#s4