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    What Is an Anti Mitochondrial antibody (IFA) Test?

    The Anti-Mitochondrial Antibody (AMA) test detects the presence of antimitochondrial antibodies in the blood, which are a highly specific and sensitive indicator of primary biliary cholangitis/cirrhosis (PBC), a chronic autoimmune liver disease. These antibodies are found in more than 95% of people with PBC.

    PBC primarily affects middle-aged individuals and is often linked to other autoimmune conditions, such as Sjögren’s syndrome. It leads to progressive liver scarring as the immune system attacks the bile ducts, which impairs liver function.

    The IFA (Immunofluorescence Assay) method used in this test enables accurate identification of AMA, particularly M2 antibodies, which are strongly associated with PBC. Early detection with this test is critical because timely intervention can help slow disease progression, reduce liver damage, and prevent liver failure.

    The AMA test is vital for diagnosing autoimmune liver diseases, monitoring liver function, and distinguishing PBC from other liver disorders. If you experience persistent liver issues or symptoms suggestive of PBC, arranging an Anti-Mitochondrial Antibody test at home can be a useful step in further evaluation.

    Anti Mitochondrial antibody (IFA) Test Parameters

    The Anti-Mitochondrial Antibody test detects antimitochondrial antibodies in the blood.

    These antibodies target the mitochondria, which are responsible for producing energy within cells, leading to potential liver damage over time. AMA is most commonly linked with autoimmune liver diseases such as primary biliary cholangitis (PBC). However, they may also be present in a small percentage of individuals with autoimmune hepatitis and other liver diseases. Since AMAs can appear long before any noticeable symptoms or liver function problems, this test is valuable for identifying autoimmune liver damage early.

    Anti Mitochondrial antibody (IFA) Test Preparation

    This guide will assist you in preparing for your Anti-Mitochondrial Antibody (IFA) test at home:

    • Prerequisites Fasting is not generally required before taking the Anti-Mitochondrial Antibody (IFA) test, though it’s advisable to check with your doctor for any specific preparation instructions.

    • Best Time to Get Tested The AMA test can be taken at any time that is most convenient for you, ensuring flexibility.

    • Who Should Get an Anti-Mitochondrial Antibody (IFA) Test? This test is recommended for those exhibiting symptoms of PBC or other autoimmune liver diseases. It may also be suggested for people with abnormal liver function tests, unexplained jaundice, or ongoing fatigue tied to liver issues.

    • Cautions Before Taking an Anti-Mitochondrial Antibody (IFA) Test Be sure to inform your doctor of any medications, recent illnesses, or autoimmune conditions, as these can affect your results.

    Why Take the Anti Mitochondrial antibody (IFA) Test?

    The Anti-Mitochondrial Antibody test is vital as it can:

    Diagnose PBC : This test is key in diagnosing primary biliary cholangitis (PBC), an autoimmune liver disease.

    Help differentiate liver diseases : It is used to differentiate PBC from other liver conditions like viral hepatitis, alcoholic cirrhosis, and bile duct blockages.

    This test is commonly recommended when symptoms indicative of PBC-related liver damage are present, such as:

    • Abdominal pain or discomfort

    • Persistent fatigue

    • Itching (pruritus)

    • Bone, muscle, and joint pain

    • Nausea and loss of appetite

    • Swelling in the ankles or abdomen due to fluid buildup

    • Dry eyes and mouth (linked to Sjögren’s syndrome)

    • Unexplained weight loss

    • Yellowing of the skin and eyes (jaundice)

    • Dark urine

    FAQs on the Anti Mitochondrial antibody (IFA) Test in Hyderabad

    The cost for the Anti-Mitochondrial Antibody (IFA) test in Hyderabad is ₹2100. This includes home sample collection within 60 minutes, with results typically available within 123 hours.

    Yes, Orange Health Labs offers home sample collection for the Anti-Mitochondrial Antibody (IFA) test. A trained eMedic will visit your location within 60 minutes of booking to collect the sample.

    The Anti-Mitochondrial Antibody test is used to diagnose primary biliary cholangitis (PBC), the Anti-Mitochondrial Antibody test is important for differentiating PBC from other liver conditions, including viral hepatitis, alcoholic cirrhosis, and bile duct blockages.

    Fasting is not needed before the Anti-Mitochondrial Antibody test, though it’s important to adhere to any particular instructions from your doctor.

    To arrange the Anti-Mitochondrial Antibody (IFA) test with Orange Health Labs, do the following:

    • Find the Test: Search for the "Anti-Mitochondrial Antibody (IFA) test" on the Orange Health Labs platform.

    • Confirm Your Appointment: Provide your details, select your location, and choose an appropriate time for sample collection.

    • Sample Collection: A professional eMedic will collect the sample from your home or office.

    • Laboratory Analysis: The sample is processed at an NABL-accredited, ICMR-approved laboratory.

    • Receive Results: The test results will be sent via email or WhatsApp within 123 hours.

    The normal reference values for the Antimicrobial Antibody Test are as follows:

    • Negative: ≤20.0 units

    • Equivocal: 20.1-24.9 units

    • Positive: ≥25.0 units.

    Results for the Anti-Mitochondrial Antibody test are typically delivered within 123 hours following sample collection.

    The test frequency depends on your doctor’s instructions. For patients diagnosed with PBC or other autoimmune liver diseases, it may be repeated regularly to monitor the progression of the disease and treatment outcomes.

    The AMA test is used to detect anti-mitochondrial antibodies in the blood, which are markers of autoimmune liver diseases, with a focus on PBC.

    Orange Health Labs offers home sample collection for the Anti-Mitochondrial Antibody (IFA) test across multiple localities in Hyderabad, including but not limited to Banjara Hills, Jubilee Hills, Gachibowli, Madhapur, Tarnaka, Abids, Koti, Mehdipatnam, Dilsukhnagar, Uppal, LB Nagar, Nallagandla, Nizampet, Attapur, Hitech City, Kondapur, Begumpet, Somajiguda, Ameerpet, Panjagutta, Kukatpally, Miyapur, Manikonda, Secunderabad, and Malkajgiri.

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    References

    1. Antimitochondrial Antibody and Antimitochondrial M2 Antibody - Health Encyclopedia - University of Rochester Medical Center.  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=167&contentid=antimitochondrial_antibody_m2
    2. Anti-mitochondrial antibody (AMA) [Internet]. South Tees Hospitals NHS Foundation Trust.  Available from:  https://www.southtees.nhs.uk/services/pathology/tests/anti-mitochondrial-antibody-ama/
    3. Antimitochondrial antibody: MedlinePlus Medical Encyclopedia [Internet].  Available from:  https://medlineplus.gov/ency/article/003529.htm
    4. Antimitochondrial antibody Information | Mount Sinai - New York.  Available from:  https://www.mountsinai.org/health-library/tests/antimitochondrial-antibody
    5. AMA: Mitochondrial Ab, McLendon Clinical Laboratories | UNC Medical Center, Hospitals – Chapel Hill, NC.  Available from:  https://www.uncmedicalcenter.org/mclendon-clinical-laboratories/available-tests/ama-mitochondrial-ab/