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    What is the Anti Nuclear Antibody (ANA) (IFA) Test?

    The ANA (Anti-nuclear Antibody) test is a blood test that detects and evaluates the pattern of antinuclear antibodies in your system. Normally, these antibodies help the immune system fight off bacteria and viruses. However, in autoimmune conditions, the immune system can become confused and start attacking the body's healthy cells. Antinuclear antibodies target the nucleus of cells, hence the name.

    Doctors use the ANA test to identify autoimmune disorders like rheumatoid arthritis or systemic lupus erythematosus (SLE). A diagnosis is made by interpreting the ANA test results in conjunction with other lab tests, patient symptoms, and a physical examination. This holistic approach helps determine whether the immune system is attacking healthy tissues and guides the appropriate treatment plan.

    If you reside in Hyderabad and are experiencing symptoms such as joint discomfort, ongoing fatigue, or recurrent skin rashes, an ANA test can be valuable in the early detection of autoimmune diseases, allowing you to begin treatment early.

    Anti Nuclear Antibody (ANA) (IFA) Test Parameters

    The ANA IFA test examines two critical factors: the titre value and the fluorescent pattern.

    Pattern: The test analyses how these antibodies bind to parts of the cell using a fluorescent dye, which makes them glow under a microscope. This glowing pattern can help identify specific autoimmune conditions like lupus, rheumatoid arthritis, or Sjögren’s syndrome. By studying these patterns, doctors can decide if more detailed testing is needed to identify specific antibodies.

    Titre Value: This parameter measures the level of antinuclear antibodies (ANAs) in the blood. The blood sample is diluted in steps until the antibodies can no longer be detected. The highest dilution at which antibodies are still found is noted as the titre. A higher titre suggests a higher number of antibodies, which may indicate a greater chance of having an autoimmune disorder.

    This ANA test is conducted using the Indirect Immunofluorescence (IFA) technique, which visualises the antibody patterns and provides important insights for diagnosing autoimmune diseases.

    Anti Nuclear Antibody (ANA) (IFA) Test Preparation

    Before you arrange an ANA test at home, remember the following:

    • Prerequisites

    The ANA test does not require you to fast before the test.

    • Best Time to Get Tested

    his test can be taken at any time of the day, as no fasting is required.

    • Who Should Get an ANA Profile Test?

    An ANA test might be needed if an autoimmune disorder is suspected by your doctor. It is suggested if you have symptoms like fever, skin rashes, extreme fatigue, joint pain, stiffness, swelling, or muscle aches. The test measures certain antibodies in your blood, helping to confirm if these symptoms are due to an autoimmune condition.

    • Cautions Before Taking the ANA Profile Test

    There are generally no special precautions or preparations needed before taking the ANA test.

    Why Take the Anti Nuclear Antibody (ANA) (IFA) Test?

    The ANA test detects antibodies linked to autoimmune disorders and is used to diagnose conditions such as:

    • Addison Disease: Affects the adrenal glands, causing symptoms like weakness and fatigue.

    • Sjögren's Syndrome: Damages glands that produce tears and saliva.

    • Systemic Lupus Erythematosus (SLE): A systemic condition that impacts skin, joints, and organs.

    • Rheumatoid Arthritis: A joint disorder marked by pain and swelling.

    • Scleroderma: Affects the skin and internal organs.

    • Autoimmune Hepatitis: Leads to liver inflammation.

    Doctors may suggest the ANA IFA test if you present with symptoms such as joint pain, fever, rashes, severe tiredness, or muscle pain to help determine if an individual is affected by an autoimmune condition.

    Anti Nuclear Antibody (ANA) (IFA) Test Results & Interpretation

    The ANA test detects antinuclear antibodies that can indicate autoimmune diseases.

    • Negative Result: No antibodies detected, which reduces the likelihood of an autoimmune disorder but does not completely rule it out.

    • Positive Result: The presence of antibodies could suggest an autoimmune condition, a viral infection, or other issues.

    • Weakly Positive Result: A weakly positive result should be followed by a repeat test in 6-8 weeks for further clarity.

    Positive results can show different antibody patterns, which provide further information about possible autoimmune diseases:

    • Centromere Pattern: Seen in certain types of scleroderma, involving proteins related to cell division.

    • Homogeneous Pattern: Linked with lupus, showing antibodies against DNA and histones.

    • Nuclear Dot Pattern: Connected to liver disease and rheumatic conditions, showing antibodies against specific nuclear proteins.

    • Nuclear Membrane Pattern: Associated with chronic fatigue syndrome and collagen disorders.

    • Nucleolus Pattern: Suggests involvement in muscle and skin diseases.

    • Cytoplasmic Patterns: Linked to liver disease, Sjögren's syndrome, and muscle disorders.

    • Speckled Pattern: Associated with lupus, Sjögren's syndrome, or rheumatoid arthritis, targeting various nuclear proteins.

    • Dense Fine Speckled (DFS): Can occur in healthy individuals and those with inflammatory conditions.

    A positive ANA test result does not diagnose an autoimmune disease on its own. Doctors will consider other tests and clinical findings for specific diagnoses of each disease.

    FAQs on Anti Nuclear Antibody (ANA) (IFA) Test in Hyderabad

    The price of the ANA test in Hyderabad is ₹ 1300. This fee includes a quick home sample collection within 60 minutes of booking, and the reports will be ready in 111 hours.

    Yes, Orange Health Labs provides home sample collection services for ANA tests in Hyderabad. Samples can be collected within 60 minutes of booking, depending on slot availability.

    The ANA test identifies antibodies that attack the nucleus of cells, aiding in the diagnosis of autoimmune diseases such as lupus and rheumatoid arthritis. A positive test result indicates the possibility of an autoimmune disorder.

    Fasting is not required for the ANA blood test.

    To book the ANA test with Orange Health Labs, follow these steps:

    • Search the Test: Find the Antinuclear Antibody/ANA test on our platform for Hyderabad or home collection and navigate to Orange Health’s page.

    • Verify and Book: Choose the test, go through any prerequisites, input your location, and finalize the booking by selecting a time slot for sample collection.

    • Sample Collection: A trained eMedic will visit your home at the selected time to collect the blood sample.

    • Lab Processing: The collected sample will be sent to our ICMR-approved and NABL-accredited laboratory for testing.

    • Receive Your Results: Results will be sent to you via email or WhatsApp within 111 hours and can be viewed through our app.

    ANA test results are either negative or positive. Elevated antibody levels often correlate with more severe disease activity and warrant additional diagnostic testing. A negative result indicates a lower chance of having an autoimmune disorder, while a positive result shows the presence of antibodies that may suggest an autoimmune condition.

    After booking your ANA test, Orange Health Labs will arrange for sample collection within approximately 60 minutes. The collection is swift, and results are usually available online within 111 hours.

    The frequency of ANA testing is tailored to your individual medical needs and will be guided by your doctor.

    This test measures the number (titre) and patterns of antibodies present. Lower titres suggest a lesser likelihood of autoimmune disease, while higher titres point to more significant disease activity. Different patterns, such as homogeneous and speckled, assist in diagnosing conditions like lupus or rheumatoid arthritis.

    Orange Health provides fast and convenient ANA testing throughout Hyderabad, with home sample collection services available in numerous localities including Banjara Hills, Jubilee Hills, Gachibowli, Madhapur, Hitech City, Kondapur, Begumpet, Somajiguda, Ameerpet, Panjagutta, Kukatpally, Miyapur, Manikonda, Secunderabad, Tarnaka, Abids, Koti, Mehdipatnam, Dilsukhnagar, Uppal, LB Nagar, Nallagandla, Nizampet, Attapur, Malkajgiri.

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    References

    1. Medline Plus. ANA (Antinuclear Antibody) Test: MedlinePlus Medical Test [Internet]  Available from:  https://medlineplus.gov/lab-tests/ana-antinuclear-antibody-test/
    2. Antinuclear Antibodies (ANA) Test [Internet].  Available from:  https://www.columbiadoctors.org/health-library/test/antinuclear-antibodies-ana-test/
    3. Fastest Anti-nuclear Antibody (ANA) (IFA) Test in Hyderabad at Best Price + Reports in 6 Hours [Internet].  Available from:  https://www.orangehealth.in/lab-test-bangalore/anti-nuclear-antibody?utm_source=seo_search&utm_medium=google&utm_campaign=seo&utm_term=anti-nuclear-antibody