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    What is Complement 4 (C4) Level Test?

    A Complement 4 (C4) test is a blood test used to measure the concentration of the C4 protein in your bloodstream. C4 is a vital component of the complement system, a group of proteins that strengthens your immune system by attacking harmful bacteria and viruses. This system includes nine key proteins (C1 through C9) that work together to protect your body. The C4 test is crucial for evaluating immune function and diagnosing specific health issues. Low levels of C4 may signify that the immune system is mistakenly targeting healthy cells, as seen in autoimmune diseases like lupus. Additionally, it could be linked to conditions such as chronic infections, blood disorders where red blood cells are destroyed too quickly, liver disease, malnutrition, or episodes of sudden swelling under the skin. Elevated C4 levels might indicate recovery from illness, effective treatment response, or conditions like digestive disorders, lung diseases, or even some cancers.

    For a comprehensive view of your immune health, additional tests may be needed.

    If you’re in Hyderabad, you can opt for the Complement 4 (C4) test at home, ensuring convenience and speedy results.

    Complement 4 (C4) Level Test Parameters

    The Complement 4 (C4) test measures one key parameter:

    • C4 complement protein levels in the bloodstream.

    Complement proteins function together as a defense system, protecting your body from harmful microorganisms like bacteria, viruses, and other pathogens. When these proteins detect a threat, they activate the immune response and form a structure called the Membrane Attack Complex (MAC). This structure attaches to the surface of harmful cells or microorganisms, creating holes in their outer layer, leading to their destruction.

    Beyond breaking down harmful cells, the complement system enhances the permeability of blood vessels, allowing white blood cells to move efficiently from the bloodstream into tissues to combat infections. It also attracts additional white blood cells to the infection site and stimulates phagocytosis, where immune cells like macrophages and neutrophils engulf and destroy harmful invaders. The complement system helps clear immune complexes from the bloodstream, ensuring your immune system functions optimally.

    Among the complement proteins, C3 and C4 are the most commonly measured because they are important in immune system processes. Specifically, C4 is vital for identifying and eliminating harmful invaders like bacteria and viruses, making it an essential component of a robust immune response.

    When an issue with immune function is suspected, blood tests measuring C3 and C4 levels are often performed. If these results are abnormal, further testing may include additional complement proteins like the C1 inhibitor, which can help identify the root cause. Measuring overall complement activity is also beneficial in determining whether any complement proteins are absent or malfunctioning.

    Complement 4 (C4) Level Test Preparation

    Here are essential details to know before you prepare for the Complement 4 (C4) test:

    Prerequisites: Fasting is not necessary before taking the Complement 4 (C4) test.

    Best Time to Get Tested: There is no particular time recommended for the C4 test. It can be conducted at any hour of the day that suits your schedule.

    Who Should Get a C4 Test: The C4 test is recommended for individuals with suspected autoimmune conditions, such as lupus or kidney-related disorders, or those with chronic infections like hepatitis. It is also used for monitoring progression or response to treatment in patients with existing autoimmune diseases.

    Cautions Before Taking C4 Test: No specific preparations or precautions are needed before undergoing the C4 test.

    Why Take the Complement 4 (C4) Level Test?

    The Complement 4 (C4) test is generally suggested when there are symptoms of autoimmune diseases such as lupus or rheumatoid arthritis (RA). Signs to watch for include:

    • Persistent mild fever without an apparent cause.

    • Butterfly-shaped rash appearing across the cheeks.

    • Unexplained hair loss that isn’t related to other conditions.

    • Frequent headaches or dizziness disrupting daily life.

    • Mouth ulcers or sores that take longer to heal.

    • Joint stiffness, swelling, or pain, particularly in the morning.

    • Numbness or colour changes in fingers or toes in cold weather or stress.

    • Swelling around the eyes, hands, or feet.

    • Sensitivity to sunlight resulting in discomfort or rashes.

    • Chest pain that worsens with deep breaths.

    • Extreme fatigue or tiredness that doesn’t improve with rest.

    The C4 test is also vital for those dealing with recurrent bacterial or fungal infections, as it evaluates the immune system's ability to defend against infections. In addition, it can be recommended for concerns regarding kidney health or indications of chronic hepatitis. For individuals with an existing autoimmune disease, this test assists in tracking disease progression and measuring response to ongoing treatments.

    FAQs on Complement 4 (C4) Level Test in Hyderabad

    The Complement 4 (C4) test in Hyderabad costs ₹895. This includes home sample collection, carried out by an expert eMedic within 60 minutes of confirming your booking.

    Yes, Orange Health Labs offers quick and reliable home sample collection services in Hyderabad. An experienced eMedic will reach your location within 60 minutes of test booking, depending on availability.

    The Complement 4 (C4) test evaluates immune function, aids in diagnosing autoimmune disorders like lupus, and monitors disease progression for improved treatment outcomes.

    No fasting is required for this test unless advised by your doctor. Always consult your doctor for personalised guidance.

    Here’s how to book your Complement 4 (C4) test at Orange Health Labs:

    Find the test : Search for the C4 test on the Orange Health app or website.

    Schedule your test : Enter your information, pick a time slot, and confirm your appointment.

    Sample collection : Once booked, an eMedic will collect your blood sample from the comfort of your home.

    Laboratory analysis : The sample will be tested in an ICMR-approved, NABL-accredited laboratory.

    Get your results : Reports will be delivered via WhatsApp, email, or accessible in the Orange Health app within 89 hours

    The typical range for Complement 4 (C4) levels is between 10 and 40 mg/dL, though this can vary slightly depending on the laboratory’s reference values.

    Once you book your C4 test, an eMedic will collect the sample from your location within 60 minutes. The test report will be delivered within 89 hours after the sample is processed.

    The frequency of this test is determined by your doctor, depending on your specific health requirements and ongoing treatment.

    This test measures one key parameter: the concentration of C4 complement protein in the bloodstream, which is crucial for immune function.

    Orange Health Labs offers home sample collection services in many regions of Hyderabad, including Banjara Hills, Jubilee Hills, Gachibowli, Madhapur, Hitech City, Kondapur, Begumpet, Somajiguda, Ameerpet, Panjagutta, Kukatpally, Miyapur, Manikonda, Secunderabad, Tarnaka, Abids, Koti, Mehdipatnam, Dilsukhnagar, Uppal, LB Nagar, Nallagandla, Nizampet, Attapur, Malkajgiri.

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    References

    1. Clinic C. C4 Complement Blood Test.  Available from:  https://my.clevelandclinic.org/health/diagnostics/c4-complement-blood-test
    2. Complement C4 (Blood).  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=167&contentid=complement_c4_blood
    3. Complement | Pathology Tests Explained.  Available from:  https://www.pathologytestsexplained.org.au/ptests-pro.php?q=Complement#more-information
    4. Wang H, Liu M. Complement C4, Infections, and Autoimmune Diseases. Frontiers in Immunology.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC8317844/