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    What is HLA-B27, Qualitative PCR Test?

    The HLA B27 Qualitative PCR Test is a blood test used to detect the presence of the HLA-B27 protein on white blood cells. This protein is part of the immune system and helps the body fight infections. However, in some individuals, the presence of HLA-B27 is associated with a higher risk of developing autoimmune diseases. Autoimmune diseases occur when the immune system attacks the body's healthy tissues, believing them to be harmful.

    Common conditions linked to HLA-B27 include:

    • Ankylosing spondylitis : Arthritis affecting the spine that causes pain and stiffness.

    • Juvenile arthritis : An inflammatory joint condition in children.

    • Reactive arthritis : Joint inflammation triggered by an infection.

    A positive HLA-B27 test result indicates the presence of HLA-B27 in the blood and an increased likelihood of developing certain autoimmune diseases. However, it does not confirm a diagnosis, as many people with HLA-B27 never develop these conditions. Additional tests such as the Erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP), X-ray, MRI scan, and urine test may be required for a more accurate diagnosis.

    A negative test result means that HLA-B27 is not present, which lowers the likelihood of these conditions. For individuals needing organ or tissue transplants, mismatched HLA types can lead to transplant rejection.

    For individuals based in Bangalore, getting the HLA B27 Qualitative PCR test at home can be convenient with the availability of home sample collection and timely results.

    HLA-B27, Qualitative PCR Test Parameters

    The HLA B27 Qualitative PCR Test measures a single parameter: the presence of the HLA-B27 antigen on white blood cells.

    The human leukocyte antigen (HLA) protein helps the immune system recognise the body's own cells and distinguish them from harmful invaders like viruses and bacteria.

    HLA proteins are classified into two groups: Class I (A, B, C) and Class II (DR, DP, DQ). While not as unique as fingerprints, HLA proteins vary from person to person and play a key role in immune function.

    The presence or absence of the HLA-B27 antigen is determined by genetics and is inherited from parents. If your close family member has an HLA-B27-related disease, such as ankylosing spondylitis, your likelihood of developing a similar condition increases if you also have HLA-B27.

    There are approximately 15 different subtypes of HLA-B27, with HLA-B27 05 and HLA-B27 02 being the most common. The presence of certain subtypes may influence the risk of developing autoimmune diseases. The relationship between HLA-B27 subtypes and disease risk is still being understood, and having HLA-B27 does not always mean a person will develop a health condition. However, its presence can provide useful information for diagnosing certain autoimmune disorders.

    HLA-B27, Qualitative PCR Test Preparation

    If you are planning to take the HLA B27 Qualitative PCR test at home, here are a few important points to consider:

    • Prerequisites

    No special preparations, like fasting, are necessary before undergoing the HLA B27 Qualitative PCR test.

    • Best Time to Get Tested

    This test can be scheduled at any time of the day based on convenience.

    • Who Should Get a HLA B27 Qualitative PCR Test?

    The HLA B27 Qualitative PCR test is recommended for individuals experiencing persistent joint pain, stiffness, or swelling, suspected autoimmune conditions, recurrent eye inflammation (uveitis), or those requiring organ or tissue transplants to ensure compatibility.

    • Cautions Before Taking a HLA B27 Qualitative PCR Test

    No specific precautionary measures are required before taking the HLA B27 Qualitative PCR test.

    Why Take the HLA-B27, Qualitative PCR Test?

    The HLA-B27 test may be recommended in various medical situations where autoimmune disorders or inflammatory conditions are suspected. The test may be advised if you experience:

    • Persistent joint pain, stiffness, or swelling that may indicate an autoimmune condition.

    • Chronic inflammation affecting the spine, neck, chest, eyes, or joints, suggesting conditions like ankylosing spondylitis or reactive arthritis.

    • Recurrent uveitis that occurs without a clear cause, potentially linked to an autoimmune disorder.

    The test is also done for:

    • Screening for ankylosing spondylitis or other HLA-B27-associated autoimmune diseases to assess the likelihood of developing these conditions.

    • Prior to an organ or bone marrow transplant to evaluate compatibility between the donor and recipient.

    The HLA B27 Qualitative PCR test is often accompanied by additional tests such as the CCP antibody, CRP, ESR, and rheumatoid factor, and X-rays to assess inflammation, joint damage, and autoimmune conditions.

    FAQs on HLA-B27, Qualitative PCR Test in Bangalore

    The HLA B27 Qualitative PCR test in Bangalore is available for ₹2500. This price includes quick home sample collection, typically within 60 minutes of booking. At Orange Health Labs, test results are delivered within 11 hours after sample collection.

    Yes, Orange Health Labs offers home sample collection for the HLA B27 Qualitative PCR test. Once your booking is confirmed, a trained eMedic professional will arrive at your location within 60 minutes to collect the sample conveniently.

    The HLA B27 Qualitative PCR test helps identify the presence of the HLA-B27 antigen, which is linked to autoimmune disorders like ankylosing spondylitis, reactive arthritis, and psoriatic arthritis. It also assists in organ transplant compatibility.

    No, fasting is not required for the HLA B27 Qualitative PCR test. You can take the test at any time of the day.

    To book an HLA B27 Qualitative PCR test with Orange Health Labs, follow these simple steps:

    • Find the Test : Search for "HLA B27 Qualitative PCR test" and select Orange Health Labs from the listed options.

    • Confirm Your Booking : Enter your details, choose your location, and select a convenient time for sample collection.

    • Sample Collection: A trained eMedic professional will visit your home to collect the blood sample.

    • Testing & Results : The sample is analysed at an NABL-accredited, ICMR-approved laboratory, and your results will be sent via email or WhatsApp within 11 hours of sample collection.

    The HLA-B27 Qualitative PCR test gives a positive or negative result. A negative result is normal, while a positive result suggests a higher risk for autoimmune diseases but doesn't confirm them. 1,3

    Test results are generally available within 11 hours after the sample is collected.

    The frequency of testing depends on your health condition, symptoms, and your doctor's recommendation.

    The HLA B27 Qualitative PCR test checks for only one parameter: the presence of HLA-B27 antigen in the blood.

    The HLA B27 Qualitative PCR test is available in multiple locations across Bangalore, including but not limited to Adugodi, Banashankari, Bannerghatta, Basavanagudi, Bellandur, BTM Layout, Chamrajpet, Cottonpet, CV Raman Nagar, Frazer Town, Giri Nagar, Hebbal, Domlur, Electronic City, Hennur, Hosur, HSR Layout, Jakkur, Jalahalli, Jaya Nagar, Kadugodi, Kammanahalli, Kengeri, Koramangala, Mahalakshmi Layout, Madiwala, Magadi Road, Malleshwaram, Marathahalli, Mathikere, Mysore Road, Nagarbhavi, Nandhini Layout, Old Airport Road, Peenya, RT Nagar, Rajaji Nagar, Rajarajeshwari Nagar, Sadashivnagar, Sahakara Nagar, Sanjay Nagar, Sarjapur, Seshadripuram, Shanthi Nagar, Shivaji Nagar, Sri Nagar, Tyagarajnagar, Uttarahalli, Vasanth Nagar, Vidyaranyapura, Vijaya Nagar, Whitefield, Yelahanka, Yeshwantpur.

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    References

    1. HLA-B27 antigen: MedlinePlus Medical Encyclopedia.  Available from:  https://medlineplus.gov/ency/article/003551.htm
    2. HLA-B27 Antigen.  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?ContentTypeID=167&ContentID=hla_b27_antigen
    3. Human leukocyte antigen (HLA) B27 | Pathology Tests Explained.  Available from:  https://www.pathologytestsexplained.org.au/ptests-pro.php?q=HLA+B27