The PR3 - c-ANCA Serum test is a blood test that detects cANCA a type of antineutrophil cytoplasmic antibodies (ANCAs) in the blood. There are two main types of ANCA, and testing can determine whether you have one of them. cANCA targets a protein called proteinase 3 (PR3), while pANCA targets a protein known as myeloperoxidase (MPO). These ANCAs are autoantibodies produced by the immune system that mistakenly attack normal tissues, specifically targeting proteins within neutrophils, which are white blood cells essential for fighting infections.

PR3 is a key contributor to the mechanisms underlying vascular necrosis. This test is used in evaluating patients with clinical features of ANCA-associated small cell vasculitis, specifically granulomatosis with polyangiitis (GPA), previously known as Wegener’s, a rare disease of unclear origin. It involves granulomatous inflammation and blood vessel inflammation ("vasculitis"), which can harm various organ systems. The most commonly affected areas include the sinuses, lungs, and kidneys, although any part of the body can be involved. ANCA measurement is also used to monitor the response to treatment.

If you live in Bangalore, consider getting a PR3 - c-ANCA Serum test to assess for vasculitis.

Prerequisites: No fasting is needed, but a blood sample is required for the PR3 - c-ANCA Serum test.

Best Time to Get Tested: The test can be conducted at any time unless your doctor suggests otherwise.

When Recommended: It should be done as per your doctor’s prescription.

Cautions: No specific precautions are necessary before taking the test.

Helps in the diagnosis of small vessel vasculitis such as granulomatosis with polyangiitis (GPA) in patients showing the relevant clinical symptoms.