How Does Ferritin Relate to Anemia of Chronic Disease?

Anemia of chronic disease (ACD) often presents with normal or elevated ferritin levels despite low iron availability. Inflammatory cytokines trap iron in storage proteins like ferritin, reducing its accessibility for red blood cell production. This contrasts with iron deficiency anemia, where ferritin levels are typically low. Identifying the cause of anemia through ferritin and other markers guides appropriate treatment.