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    NIPT for All Chromosomes217261100049% off
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    What is NIPT for All Chromosomes Test?

    Non-Invasive Prenatal Testing (NIPT) is a blood test done during pregnancy to check if the baby has a higher chance of certain genetic conditions. During pregnancy, tiny fragments of the baby’s DNA (cell-free DNA or cfDNA), originating from the placenta, circulate in the mother's bloodstream. NIPT analyses cfDNA to detect foetal chromosomal abnormalities without the need for invasive procedures like amniocentesis (testing amniotic fluid) or chorionic villus sampling (CVS-testing placental tissue) CVS. It helps identify disorders caused by missing or extra chromosomes.

    NIPT is primarily used to screen for:

    • Trisomies : The presence of an extra chromosome, e.g., Trisomy 21 (Down syndrome - the most common genetic condition), Trisomy 18 (Edwards syndrome) and Trisomy 13 (Patau syndrome).

    • Sex chromosome aneuploidies: Abnormal number of X or Y chromosomes, e.g., Turner syndrome, Klinefelter syndrome, and Triple X syndrome.

    • Microdeletions: Some panels can also screen for microdeletions like 22q11.2.

    NIPT has the advantage over other tests as it is non-invasive and requires only a blood sample collection, whereas other tests used for chromosomal abnormality detection are invasive.

    NIPT is a screening test, meaning it estimates the risk but does not confirm a diagnosis. If NIPT shows a high risk, further tests like amniocentesis or CVS may be ordered to confirm the findings.

    For individuals residing in Bangalore, the NIPT test at home is convenient with home collection of the sample and quick test results.

    NIPT for All Chromosomes Test Parameters

    The NIPT test measures two key parameters: chromosomal abnormalities (e.g., Down syndrome-trisomy 21, trisomy 18, and trisomy 13) and sex chromosome abnormalities (e.g., Klinefelter syndrome, Turner syndrome, Triple X syndrome, and XYY syndrome). NIPT examines cfDNA (small fragments of baby’s DNA found in mother’s blood) to check for genetic conditions.These fragments originate from the placenta, an organ that provides oxygen and nutrients to the baby. The test is typically performed after the 10th week of pregnancy because, by this time, there is enough foetal DNA in the mother’s blood for accurate results. NIPT is highly accurate for detecting Down syndrome (99%) but slightly less accurate for conditions like trisomy 18 and trisomy 13. Some factors, such as carrying twins, being a surrogate, or maternal obesity, can affect the results.

    For the test to work, the foetal fraction, which is the percentage of cfDNA in maternal blood from the placenta, must be at least 4%. If there is not enough baby’s DNA in the mother’s blood, the test might not give clear or correct results. This can happen if the test is done too early, if there is a problem with the sample, or if the mother has a higher body weight. Different NIPT methods analyse cfDNA. Most count all cfDNA fragments to detect extra or missing chromosomes.

    NIPT for All Chromosomes Test Preparation

    To ensure accurate results, follow these essential guidelines before undergoing the NIPT test:

    • Prerequisites: No special requirements, such as fasting, are needed before the NIPT test.

    • Best Time to Get Tested: The NIPT test can be performed at any time throughout the day. It is typically done from the 10th week of pregnancy onward, since foetal DNA levels may be too low before then.

    • Who Should Get a NIPT Test?: Pregnant individuals with a high risk of a child having chromosomal abnormalities should undergo this test. The test is also offered to all pregnant individuals.

    • Cautions Before Taking a NIPT Test: There are no special precautions to be taken before undergoing the NIPT test.

    Why Take the NIPT for All Chromosomes Test?

    NIPT is recommended in pregnant individuals where the foetus may be at risk of genetic conditions, for example:

    Pregnant individuals of all risk levels: Initially recommended only for high-risk pregnancies, NIPT is now advised for all pregnant individuals, regardless of their risk level.

    Parents with a family history of genetic disorders: Individuals who have a child with a chromosomal abnormality may consider NIPT to assess the likelihood of similar conditions in their current pregnancy.

    Individuals with concerning ultrasound results: If an ultrasound detects possible abnormalities in foetal development, NIPT can help assess the risk of certain genetic conditions.

    People with abnormal early screening results: If previous prenatal tests suggest a potential issue, NIPT can provide a more accurate evaluation of chromosomal abnormalities.

    Expectant parents seeking comprehensive genetic screening: As genetic testing technology advances, NIPT is expanding to detect additional genetic disorders, providing valuable early insights for prenatal care.

    NIPT can detect common chromosomal disorders like Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), and Patau syndrome (trisomy 13) with high accuracy (94-99%). It can also identify sex chromosome disorders, such as Turner syndrome (a missing X chromosome) and Klinefelter syndrome (an extra X chromosome in males).

    FAQs on NIPT for All Chromosomes Test in Bangalore

    The cost of a NIPT test in Bangalore is ₹11000. This includes home sample collection within 60 minutes of booking. Test results are delivered within 261 hours after sample collection.

    Yes, Orange Health Labs provides doorstep sample collection for NIPT testing. After scheduling the test, a trained eMedic expert will arrive at your location within 60 minutes to collect the required sample.

    NIPT is used to screen for genetic issues (e.g., Down syndrome, Edwards syndrome, and Patau syndrome) and sex chromosome conditions (e.g., Klinefelter syndrome), and assesses the risks for chromosomal disorders during pregnancy.

    Fasting is not needed before undergoing the NIPT test.

    To schedule an NIPT test with Orange Health Labs, follow these steps:

    • Find the Test: Search for “NIPT test” and select the Orange Health Labs from the list.

    • Confirm Appointment: Enter your details, select your location, and choose a suitable sample collection time.

    • Sample Collection: A trained eMedic will visit your location and collect the blood sample.

    • Processing and Results: The sample is analysed at our NABL-certified, ICMR-approved laboratory. Results will be shared via email or WhatsApp within 261 hours.

    NIPT results are presented as a “Z score”. Typically, a Z score between the range specified for each condition is considered low risk for the condition. E.g., a Z score in the range of -6 to 2.8 is considered low risk for Down syndrome.

    The test reports are usually available within 261 hours after the sample has been collected.

    The necessity and frequency of this test depend entirely on your specific medical condition and the advice of your doctor.

    The NIPT test includes screening for trisomy 21 (Down syndrome), trisomy 18, trisomy 13, and sex chromosome abnormalities like Klinefelter syndrome, Turner syndrome, Triple X syndrome, and XYY syndrome.

    The NIPT test is accessible in various localities across Bangalore, including but not limited to Adugodi, Banashankari, Bannerghatta, Basavanagudi, Bellandur, BTM Layout, Chamrajpet, Cottonpet, CV Raman Nagar, Frazer Town, Giri Nagar, Hebbal, Domlur, Electronic City, Hennur, Hosur, HSR Layout, Jakkur, Jalahalli, Jaya Nagar, Kadugodi, Kammanahalli, Kengeri, Koramangala, Mahalakshmi Layout, Madiwala, Magadi Road, Malleshwaram, Marathahalli, Mathikere, Mysore Road, Nagarbhavi, Nandhini Layout, Old Airport Road, Peenya, RT Nagar, Rajaji Nagar, Rajarajeshwari Nagar, Sadashivnagar, Sahakara Nagar, Sanjay Nagar, Sarjapur, Seshadripuram, Shanthi Nagar, Shivaji Nagar, Sri Nagar, Tyagarajnagar, Uttarahalli, Vasanth Nagar, Vidyaranyapura, Vijaya Nagar, Whitefield, Yelahanka, Yeshwantpur.

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    References

    1. Cleveland Clinic. NIPT test (Noninvasive Prenatal Testing): What To Expect.  Available from:  https://my.clevelandclinic.org/health/diagnostics/21050-nipt-test
    2. Medline Plus. What is noninvasive prenatal testing (NIPT) and what disorders can it screen for?: MedlinePlus Genetics  Available from:  https://medlineplus.gov/genetics/understanding/testing/nipt/
    3. Non-invasive Prenatal Screening or Testing (NIPS / NIPT).  Available from:  https://me.health.gov.il/en/parenting/planning-a-family/pregnancy-testing-and-monitoring/tests-during-pregnancy/nipt-test/
    4. Prenatal Screening and Diagnostic Considerations for 22q11.2 Microdeletions. Genes.  Available from:  https://www.mdpi.com/2073-4425/14/1/160