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    What is Complement 4 (C4) Level Test?

    The Complement 4 (C4) test is a basic yet highly effective blood test that evaluates the levels of C4 protein in your body. C4 plays a key role in the complement system, a specialised group of proteins that boosts your immune defense by targeting harmful bacteria and viruses. This system comprises nine primary proteins (C1 through C9) that work in tandem to ensure your body’s protection. Doctors often use the C4 test to evaluate immune functionality and detect specific medical conditions. A drop in C4 levels may suggest that your immune system is mistakenly attacking healthy tissues, commonly seen in autoimmune conditions like lupus. Low levels can also be linked to chronic infections, blood disorders causing excessive red blood cell breakdown, liver conditions, malnutrition, or sudden swelling episodes under the skin. Conversely, increased C4 levels might indicate that your body is recovering from an illness, responding well to treatment, or dealing with conditions such as digestive or lung disorders and, in some cases, cancers.

    To gain a thorough understanding of your immune system’s health, additional tests may be required.

    If you are based in Delhi, you can schedule the Complement 4 (C4) test at home, ensuring both convenience and timely results.

    Complement 4 (C4) Level Test Parameters

    The Complement 4 (C4) test measures one vital parameter:

    • Concentration of C4 complement protein in the blood.

    Complement proteins work collectively as a key part of your immune system, defending against harmful microorganisms like bacteria and viruses. When a threat is identified, these proteins activate the immune response and form a structure called the Membrane Attack Complex (MAC). The MAC attaches to harmful cells or microorganisms, piercing their outer membrane and causing them to disintegrate.

    In addition to breaking down harmful microorganisms, the complement system boosts immune response in multiple ways. It increases blood vessel permeability, allowing white blood cells to exit the bloodstream and reach affected tissues. The complement system also attracts more white blood cells to the site of infection and promotes phagocytosis, a process where immune cells such as macrophages and neutrophils engulf harmful microorganisms. Furthermore, it helps clear immune complexes from circulation, supporting optimal immune system performance.

    Among the complement proteins, C3 and C4 are the most frequently measured because they play a central role in immune processes. C4 is especially critical for identifying and combating harmful pathogens like bacteria and viruses, making it an integral part of your body’s ability to fight infections effectively.

    When immune dysfunction is suspected, healthcare providers often recommend measuring C3 and C4 levels. If abnormalities are detected, further testing may include other complement proteins, such as C1 inhibitors, to identify the underlying issue. Testing overall complement activity can also help determine if any proteins in the system are missing or not functioning as expected.

    Complement 4 (C4) Level Test Preparation

    Here’s what you need to know about getting ready for the Complement 4 (C4) test:

    Prerequisites: There is no need to fast before undergoing the Complement 4 (C4) test.

    Best Time to Get Tested: There are no time restrictions for taking the C4 test. You can book and complete the test based on your convenience and availability.

    Who Should Get a C4 Test: This test is suitable for individuals suspected of having autoimmune disorders like lupus or kidney disease, or for those diagnosed with chronic conditions like hepatitis. It’s also valuable for monitoring autoimmune disease progression or treatment effectiveness.

    Cautions Before Taking C4 Test: No special precautions or measures are required before the C4 test.

    Why Take the Complement 4 (C4) Level Test?

    The Complement 4 (C4) test is recommended for individuals showing signs of autoimmune disorders such as lupus or rheumatoid arthritis (RA). Some common symptoms include:

    • Frequent dizziness or unexplained headaches.

    • Persistent low-grade fever without a clear cause.

    • Joint stiffness, swelling, or pain affecting mobility.

    • Butterfly-shaped rash across the cheeks.

    • Sensitivity to sunlight that triggers skin rashes or discomfort.

    • Mouth sores or ulcers that persist or recur.

    • Swelling around the eyes, hands, or feet.

    • Extreme fatigue or lack of energy, even after resting.

    • Unexplained hair loss or thinning hair.

    • Chest pain, especially during deep breaths.

    • Numbness or changes in finger and toe colour, especially in cold or stressful situations.

    In addition, this test is recommended for people with recurring bacterial or fungal infections, as it evaluates how well the immune system fights off these threats. The C4 test can also help identify kidney function issues or signs of chronic hepatitis. For those managing an autoimmune disorder, it plays a key role in monitoring disease progression and determining the effectiveness of treatment plans.

    FAQs on Complement 4 (C4) Level Test in Delhi

    The cost of a Complement 4 (C4) test in Delhi is ₹895. This fee includes seamless home sample collection, performed within 60 minutes of booking confirmation.

    Yes, Orange Health Labs provides home sample collection for the Complement 4 (C4) test in Delhi. A skilled eMedic, will visit your home within 60 minutes of booking your test, subject to slot availability.

    The Complement 4 (C4) test helps diagnose autoimmune diseases, assess immune function, and monitor conditions like lupus and rheumatoid arthritis for better management.

    No fasting is required before this test unless your doctor specifically advises otherwise. Always follow your doctor’s instructions closely.

    To book the Complement 4 (C4) test at Orange Health Labs in Delhi:

    Search for the test : Use the Orange Health website or app to locate the C4 test.

    Confirm your booking : Provide your details, select a time slot, and finalize your appointment.

    Sample collection : After confirmation, a professional eMedic will collect your blood sample from your preferred location.

    Laboratory processing : The sample is tested in an NABL-accredited, ICMR-approved laboratory for analysis.

    Receive your report : Results are sent via WhatsApp or email within 72 hours and are also available on the Orange Health app.

    The normal range for C4 levels falls between 10 and 40 mg/dL, but these values might slightly differ based on the laboratory’s equipment and testing standards.

    After confirming your booking, an eMedic will collect the blood sample from your home within 60 minutes. Your report will be delivered within 72 hours of sample processing.

    The need for repeating this test depends on your ongoing health status and doctor’s advice to monitor conditions like autoimmune diseases.

    The C4 test measures only one parameter: the amount of C4 complement protein in the blood, which plays an important role in immune defense.

    Orange Health Labs provides doorstep sample collection for C4 testing in numerous areas of Delhi, such as Connaught Place, Chandni Chowk, Karol Bagh, Lajpat Nagar, South Extension, Greater Kailash, Hauz Khas, Saket, Vasant Kunj, Dwarka, Rohini, Pitampura, Janakpuri, Rajouri Garden, Mayur Vihar, Preet Vihar, Shahdara, Laxmi Nagar, Green Park, Safdarjung Enclave, Defence Colony, New Friends Colony, Kalkaji, Malviya Nagar, Nehru Place.

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    References

    1. Clinic C. C4 Complement Blood Test.  Available from:  https://my.clevelandclinic.org/health/diagnostics/c4-complement-blood-test
    2. Complement C4 (Blood).  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=167&contentid=complement_c4_blood
    3. Complement | Pathology Tests Explained.  Available from:  https://www.pathologytestsexplained.org.au/ptests-pro.php?q=Complement#more-information
    4. Wang H, Liu M. Complement C4, Infections, and Autoimmune Diseases. Frontiers in Immunology.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC8317844/