The Sickling test is a diagnostic test used to check for sickle cell disease (SCD) by detecting the presence of sickle hemoglobin (HbS) in the blood. Sickle cell disease is caused by a mutation in the beta-globin gene, which changes the shape of red blood cells into a crescent or "sickle" shape. These sickle-shaped cells can block blood flow, causing pain and potential damage to tissues. The Sickling test uses a chemical reaction involving sodium dithionite to make HbS insoluble, leading to visible changes that can be compared to normal samples. While this test is simple and cost-effective, it has some limitations, such as false negatives in newborns and those with co-inherited alpha-thalassemia. It also cannot distinguish between sickle cell trait (SCT) and sickle cell disease (SCD), and may show false positives in certain situations. If you live in Delhi, you can conveniently schedule a Sickling test to check for sickle cell disease.

Prerequisites: Fasting is not necessary, a blood sample is required for the test. Best Time to Get Tested: The test can be taken at any time of the day unless otherwise advised by a doctor. When Recommended: To be conducted as per the doctor’s prescription. Cautions: No specific precautions are required before the test.

Detects abnormal haemoglobin (HbS) that causes sickle cell disease or sickle cell trait. It helps identify individuals with the condition, although it cannot distinguish between sickle cell disease and sickle cell trait, which requires further testing like haemoglobin electrophoresis.