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    What is Tissue Transglutaminase antibody IgA Test?

    The Anti-Tissue Transglutaminase (tTG-IgA) test is an essential blood test used to help diagnose coeliac disease and dermatitis herpetiformis. Coeliac disease is an autoimmune disorder in which the immune system mistakenly identifies gluten, a protein in wheat, rye, barley, and oats, as harmful. This immune response triggers the production of antibodies that attack tissue transglutaminase (tTG), an enzyme that supports the health of the gut lining, leading to damage and inflammation.

    This test is recommended for individuals experiencing symptoms like persistent digestive discomfort or nutritional deficiencies. It is also suggested for people with a family history of coeliac disease, thyroid disorders, type 1 diabetes, or other autoimmune diseases associated with gluten intolerance.

    If you are based in Delhi and suspect gluten sensitivity or are at risk of coeliac disease, you can schedule the Anti Tissue Transglutaminase test from home.

    Tissue Transglutaminase antibody IgA Test Parameters

    The tTG-IgA test detects IgA anti-tissue transglutaminase antibodies, which are important markers of coeliac disease.

    These antibodies are produced when the immune system mistakenly attacks an enzyme called tissue transglutaminase (tTG) after eating gluten. The test is highly reliable, with over 90% accuracy, making it essential for diagnosing coeliac disease and monitoring its activity.

    These antibodies often appear early, even before symptoms like bloating or weight loss begin. Most untreated patients with coeliac disease have both IgA anti-tTG and IgA anti-endomysial antibodies. Following a gluten-free diet gradually reduces these antibodies, and they may eventually disappear. This makes the test useful for diagnosis and tracking dietary compliance.

    Tissue Transglutaminase antibody IgA Test Preparation

    Here’s a guide to help you get ready for the IgA anti-tTG test:

    • Prerequisites: You don’t need to fast beforehand for the Anti Tissue Transglutaminase test.

    • Best Time to Get Tested: The Anti Tissue Transglutaminase test can be done at any time that works for you, morning or afternoon.

    • Who Should Get an Anti-Tissue Transglutaminase Test?: People with symptoms of coeliac disease, such as persistent diarrhoea, belly pain, poor growth, or skin rashes, should consider this test. It’s also recommended for those with a family history of coeliac disease or conditions like type 1 diabetes and thyroid dysfunction.

    • Cautions Before Taking an Anti-Tissue Transglutaminase Test: The test should be done while eating a diet that includes gluten, as avoiding gluten can result in lower antibody levels and less accurate results.

    Why Take the Tissue Transglutaminase antibody IgA Test?

    You may need the Anti-Tissue Transglutaminase test if you:

    Experience coeliac disease symptoms , which include:

    o Bloating

    o Abdominal discomfort

    o Skin rashes

    o Chronic diarrhoea

    o Constipation

    o Vomiting

    o Stunted growth

    Have autoimmune diseases , such as type 1 diabetes or thyroid dysfunction, as these are often related to coeliac disease.

    Have close relatives with coeliac disease , as this increases your risk of developing the condition.

    FAQs on Tissue Transglutaminase antibody IgA Test in Delhi

    In Delhi, the Anti-Tissue Transglutaminase test is priced at ₹1309, including doorstep sample collection within 60 minutes. Test results will be available in 84 hours after sample collection.

    Yes, Orange Health Labs provides home collection for the Anti-Tissue Transglutaminase test. A trained eMedic will collect your sample safely and professionally within 60 minutes of booking.

    This test measures IgA antibodies targeting tissue transglutaminase, making it essential for diagnosing gluten intolerance and coeliac disease. It also monitors response to dietary changes and identifies related conditions like dermatitis herpetiformis.

    No, fasting is not needed for the Anti Tissue Transglutaminase test. You can have your meals as usual before the test.

    To book an Anti-Tissue Transglutaminase test with Orange Health Labs, follow these steps:

    Search Online : Locate "Anti-Tissue Transglutaminase test" on the Orange Health Labs platform.

    Enter Details : Provide your contact information, select your location, and confirm a time slot.

    Sample Collection : A healthcare professional will visit to take the sample.

    Lab Testing : Your sample will be processed at a an NABL-accredited, ICMR-approved laboratory.

    Receive Results : Get your test report digitally within 84 hours via email or WhatsApp.

    Normal levels are indicated by the absence of IgA anti-tTG antibodies (negative). Positive antibody levels often suggest coeliac disease or gluten sensitivity.

    In Delhi, test reports of the Anti-tTG IgA test are available within 84 hours after sample collection

    Typically, this test is performed during diagnosis and repeated as necessary to monitor the effectiveness of a gluten-free diet or assess disease activity.

    It measures IgA anti-tTG antibodies, which are markers of an autoimmune response linked to coeliac disease.

    Orange Health Labs provides home sample collection for the Anti-Tissue Transglutaminase test in localities in Delhi like Connaught Place, Chandni Chowk, Karol Bagh, Lajpat Nagar, South Extension, Greater Kailash, Hauz Khas, Saket, Vasant Kunj, Dwarka, Rohini, Pitampura, Janakpuri, Rajouri Garden, Mayur Vihar, Preet Vihar, Shahdara, Laxmi Nagar, Green Park, Safdarjung Enclave, Defence Colony, New Friends Colony, Kalkaji, Malviya Nagar, Nehru Place.

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    References

    1. Blood Test: Tissue Transglutaminase IgA (tTg-IgA) (for Parents).  Available from:  https://kidshealth.org/en/parents/test-ttg.html
    2. Tissue Transglutaminase Antibody (TTG) - South Tees Hospitals NHS Foundation Trust.  Available from:  https://www.southtees.nhs.uk/services/pathology/tests/tissue-transglutaminase-antibody-ttg/
    3. Pathology Handbook.  Available from:  https://www.pathology.med.umich.edu/handbook/#/details/1217