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    What Is the Acetyl Choline Receptor Binding antibody Test?

    The Acetylcholine Receptor (AChR) Antibody test is a diagnostic blood test designed to identify antibodies that attack acetylcholine receptors, crucial for communication between nerves and muscles. Acetylcholine, a neurotransmitter, binds to receptors on muscle cells, triggering muscle contractions. In myasthenia gravis (MG), an autoimmune disorder, the immune system creates abnormal AChR antibodies, disrupting this process and causing muscle weakness and fatigue.

    This test is especially helpful for diagnosing neuromuscular disorders related to acetylcholine function. It plays a significant role when clinical signs like muscle weakness, breathing difficulties, drooping eyelids (ptosis), or speaking problems point to MG, but further confirmation is needed. Additionally, it can be used to track treatment progress in thymoma and MG, as antibody levels often drop with successful intervention.

    In Delhi, individuals needing to check their AChR antibody levels can conveniently arrange for the Acetylcholine Receptor Antibody test at home.

    Acetyl Choline Receptor Binding antibody Test Parameters

    The AChR antibody test determines the level of autoantibodies targeting acetylcholine receptors in the bloodstream.

    Acetylcholine is essential for muscle contraction. In people with myasthenia gravis (MG), the body produces antibodies against the AChR protein, which disrupts acetylcholine’s normal function. AChR antibodies affect these receptors which are responsible for transmitting signals from nerves to muscles. These autoantibodies impair neuromuscular communication by blocking, destroying, or altering the acetylcholine receptors at the neuromuscular junction. They are typically found in 85-90% of individuals with generalized forms of the disease.

    Acetyl Choline Receptor Binding antibody Test Preparation

    Getting ready for the AChR antibody test is straightforward. Here's how to prepare:

    • Prerequisites: No special steps like fasting are needed before taking the test.

    • Best Time to Get Tested: You can schedule the AChR Antibody test at any time of the day.

    • Who Should Get an Acetylcholine Receptor Antibody Test?: This test is useful for people who are showing signs of myasthenia gravis, such as muscle weakness, droopy eyelids, swallowing difficulties, or speech issues. It is also recommended for individuals with suspected autoimmune neuromuscular disorders or thymomas.

    • Cautions Before Taking an Acetylcholine Receptor Antibody Test: Certain medications, including muscle relaxants and anaesthetics, may interfere with the results. Be sure to inform your doctor about any treatments you're currently undergoing.

    Why Take the Acetyl Choline Receptor Binding antibody Test?

    The AChR Antibody test plays a critical role in identifying Myasthenia Gravis (MG), an autoimmune neuromuscular disorder. Early detection is key to controlling symptoms and enhancing the overall quality of life. This test is typically suggested when symptoms such as the following are observed:

    • Eyelid drooping (ptosis)

    • Muscle weakness, particularly in the arms, legs, neck, and fingers

    • Difficulty with speech

    • Issues with swallowing and chewing

    • Breathing problems

    • Problems with balance and walking

    FAQs on Acetyl Choline Receptor Binding antibody Test in Delhi

    The Acetylcholine Receptor (AChR) Antibody test cost in Delhi is ₹3630, including home sample collection within 60 minutes of booking, and test results available within 132 hours after sample collection.

    Yes, home sample collection for the AChR Antibody test is available with Orange Health Labs. Within 60 minutes of booking, a trained eMedic will visit your location to collect the sample.

    The Acetylcholine Receptor Antibody test is mainly used to diagnose myasthenia gravis by assessing for the presence of antibodies that interfere with neuromuscular communication. It helps diagnose conditions like MG and thymoma and monitor treatment response.

    No, fasting is not required for the Acetylcholine Receptor Antibody test.

    To book the test with Orange Health Labs, just follow these steps:

    • Search & Select: Look for the "Acetylcholine Receptor Antibody test" and select Orange Health Labs.

    • Confirm the Appointment: Enter your details, choose your location, and select a convenient time for sample collection.

    • Sample Collection: A trained eMedic will collect the sample from your chosen location.

    • Test and Results: The sample will be analysed at an NABL-accredited, ICMR-approved laboratory and you will receive your results via email or WhatsApp within 132 hours.

    The normal Acetylcholine Receptor Antibody levels typically fall below 0.05nmol/L. Undetectable or low levels are considered within the healthy range, while higher values may indicate the presence of myasthenia gravis or other neuromuscular conditions. The interpretation of these results will be guided by your symptoms and medical background, as assessed by your doctor.

    The test results are usually available within 132 hours of sample collection.

    The frequency of your testing will be based on the advice of your doctor. Typically, this test is requested if myasthenia gravis is suspected or to track the progress of the condition and response to treatment. Your doctor will decide if further testing is required depending on your specific situation.

    This test measures the levels of acetylcholine receptor antibodies in the blood, which are involved with blocking the acetylcholine receptors at the neuromuscular junction.

    With Orange Health Labs, you can conveniently undergo the Acetylcholine Receptor Antibody test in the comfort of your home or office. You can request sample collection service at various localities in Delhi, including Connaught Place, Chandni Chowk, Karol Bagh, Lajpat Nagar, South Extension, Greater Kailash, Hauz Khas, Saket, Vasant Kunj, Dwarka, Rohini, Pitampura, Janakpuri, Rajouri Garden, Mayur Vihar, Preet Vihar, Shahdara, Laxmi Nagar, Green Park, Safdarjung Enclave, Defence Colony, New Friends Colony, Kalkaji, Malviya Nagar, Nehru Place.

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    References

    1. Acetylcholine Receptor Antibody (Blood) - Health Encyclopedia - University of Rochester Medical Center.  Available from:  https://www.urmc.rochester.edu/encyclopedia/content?contenttypeid=167&contentid=acetylcholine_receptor_antibody_blood
    2. Acetylcholine receptor antibody: MedlinePlus Medical Encyclopedia.  Available from:  https://medlineplus.gov/ency/article/003576.htm
    3. Acetylcholine Receptor Antibody.  Available from:  https://www.ucsfhealth.org/medical-tests/acetylcholine-receptor-antibody
    4. Journal of Neurology Neurosurgery & Psychiatr.  Available from:  https://pmc.ncbi.nlm.nih.gov/articles/PMC490626/
    5. ‌Acetylcholine receptor antibody Information | Mount Sinai - New York.  Available from:  https://www.mountsinai.org/health-library/tests/acetylcholine-receptor-antibody