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    What is an Extended Thyroid Profile Test?

    Thyroid tests help determine how well the thyroid, a small, butterfly-shaped gland located in the neck, is functioning. This gland produces T3 (triiodothyronine) and T4 (thyroxine), hormones that control the body’s energy use and influence crucial processes like heart rate, digestion, breathing, mood, and weight. T3 is the active hormone that drives metabolism, while T4 acts as a reserve that stays in the body longer. A thyroid test may be recommended by your doctor if you're showing signs like irritability, fatigue, restlessness, sluggishness, or unexpected weight changes. These tests help diagnose thyroid disorders such as hyperthyroidism (high thyroid hormone levels) and hypothyroidism (low thyroid hormone levels).

    The Extended Thyroid Profile consists of tests for thyroid-stimulating hormone (TSH), total T4, total T3, free T4 (FT4), and free T3 (FT3). TSH, produced by the pituitary gland, manages the thyroid’s production of T4 and T3. Both T4 and T3 exist in bound and free forms, but only FT4 and FT3, the unbound versions, can enter tissues to have a direct effect.

    In a fast-paced city like Delhi, common thyroid symptoms, such as fatigue and mood changes, can be overlooked. If you notice any of these symptoms, consider getting an Extended Thyroid Profile test in Delhi.

    Extended Thyroid Profile Test Parameters

    The Extended Thyroid Profile examines five primary parameters to assess thyroid function:

    TSH

    Produced by the pituitary, TSH stimulates the thyroid to release T4 and T3.

    Total T4

    This parameter measures the total amount of T4, including both its bound and unbound forms. The bound form cannot enter tissues.

    Total T3

    This parameter measures the total T3, including the bound form that is unable to enter tissues.

    Free T4

    This parameter evaluates the biologically active free form of T4 that can enter body tissues.

    Free T3

    This parameter measures the unbound form of T3 that is biologically active and can affect tissues.

    TSH regulates thyroid hormone levels in a feedback loop: when T4 is low, TSH increases, and when T4 is high, TSH decreases. T4 is then converted to T3 mainly in the liver and brain. This test gives a detailed look into thyroid health, supporting diagnosis and treatment.

    Extended Thyroid Profile Test Preparation

    Be mindful of the following points before scheduling an Extended Thyroid Profile test at home:

    • Prerequisites

    Fasting is not required for the Extended Thyroid Profile test, though your doctor might occasionally advise it for more accurate results. Be sure to consult with your doctor to see if fasting is necessary for your individual case.

    • Best Time to Get Tested

    The morning is the best time for thyroid testing, as food may interfere with the test results. Testing at the same time each day helps maintain consistency in your results.

    • Who Should Get an Extended Thyroid Profile Test

    Those experiencing symptoms like fatigue, sluggishness, restlessness, irritability, or unexplained weight changes should consider taking this test. It’s also recommended for individuals with a family history of thyroid problems, pregnant women, those facing fertility issues, or people undergoing thyroid treatment.

    • Cautions Before Taking an Extended Thyroid Profile Test

    No special preparation is needed, but make sure to notify your doctor about any medications you are currently taking, especially those related to thyroid disorders.

    Why Take a Extended Thyroid Profile Test?

    Changes in thyroid hormone levels can influence your health. An Extended Thyroid test may be recommended if you're:

    • Noticing symptoms of hyperthyroidism such as:

    • Heat sensitivity

    • Weight loss

    • Light or absent menstruation

    • Rapid heartbeat

    • Excessive sweating

    • Sleeping problems

    • Nervousness

    • Increased bowel movements

    • Noticing symptoms of hypothyroidism such as:

      • Cold sensitivity

      • Weight gain

      • Heavy menstruation

      • Slow heart rate

      • Dry skin

      • Fatigue

      • Weakness

      • Muscle aches

      • Constipation

    Those with the following health conditions may also need to undergo a Thyroid test:

    • Taking thyroid hormone replacement therapy

    • Pregnancy

    • Turner syndrome

    • Residence in an area without iodised salt, which increases the risk of iodine deficiency

    • Age over 60, particularly women

    • Undergoing infertility investigations

    • History of radiation therapy to the head and/or neck

    • Autoimmune diseases, such as:

      • Celiac disease

      • Addison’s disease (primary adrenal insufficiency)

      • Pernicious anaemia

      • Type 1 diabetes

      • Lupus

      • Rheumatoid arthritis

      • Sjögren’s syndrome

    Extended Thyroid Profile Test Results & Interpretation

    The table below provides the normal ranges for different parameters included in the Extended Thyroid Profile test:

    Test ParameterReference Range
    Triiodothyronine (T3), Free2.77-5.27 pg/mL
    Thyroxine (T4), Free0.78-2.19 ng/dL
    Triiodothyronine (T3), Total0.97-1.69 ng/dL
    Thyroxine (T4), Total5.53-11.0 µg/dL
    Thyroid Stimulating Hormone (TSH)0.400-4.049 µIU/mL

    However, in pregnant women, the reference range for TSH differs. For the precise values, please see the table below:

    TrimesterReference Range (µIU/mL)
    1st Trimester0.100-2.500
    2nd Trimester0.200-3.00
    3rd Trimester0.300-3.00

    Interpretation of Abnormal levels

    T4 and FT4

    Low T4/FT4 levels may indicate:

    • Hypothyroidism

    • Congenital hypothyroidism (present from birth in infants)

    • Medication side effects

    • Thyroiditis (inflammation of the thyroid gland)

    High T4/FT4 levels may indicate:

    • Hyperthyroidism

    • Excess dietary iodine

    • Overactive thyroid gland with a lump or areas that produce excess thyroid hormones (toxic nodule/goitre)

    • A tumour (noncancerous) in the pituitary gland

    • Thyroiditis

    T3 and FT3

    High T3/FT3 Levels:

    • Indicate hyperthyroidism

    • With low TSH and high FT4 suggest a thyroid gland problem causing excess thyroid hormone secretion

    • With normal or high TSH and high FT4 suggest a pituitary gland issue causing excess thyroid hormone secretion

    Low T3/FT3 Levels:

    • Indicate hypothyroidism

    • Normal or low T3 levels with low TSH and low FT4 indicate a pituitary gland problem causing less secretion of thyroid hormone

    • Normal or low T3 levels with high TSH and low FT4 indicate a thyroid gland issue causing less secretion of thyroid hormone

    TSH Levels

    High levels of TSH typically indicate primary hypothyroidism (caused due to issues in the thyroid gland).

    Low TSH levels suggest hyperthyroidism.

    Factors Influencing TSH Levels

    • Meal Timings and Circadian Rhythm : TSH levels can fluctuate with food intake and throughout the day. Significant variations are observed both with meal consumption and at different times of the day.

    • Additional Influences : TSH is a sensitive hormone influenced by factors beyond thyroid function. These include stress, physical activity, genetic factors, exposure to toxins and radiation, thyroid gland inflammation, iodine levels in the diet, pregnancy, non-thyroidal pituitary factors (such as glucocorticoids, somatostatin, and dopamine), and certain medications that can impact the TSH and free T4 relationship.

    FAQs on Extended Thyroid Profile Test in Delhi

    The Extended Thyroid Profile test price is ₹ 1270. This cost includes the fastest home sample collection within 60 minutes of test booking, with results available within 6 hours.

    Yes, Orange Health Labs offers home sample collection for the Extended Thyroid Profile test in Delhi. After test confirmation, your sample will be collected at home within 60 minutes, depending on the availability of slots.

    The Extended Thyroid Profile test is designed to:

    • Check thyroid function by assessing TSH, FT4, total T4, FT3, and total T3 levels.

    • Diagnose thyroid conditions, including hypo- and hyperthyroidism.

    • Monitor the effectiveness of thyroid hormone therapy and check for pituitary issues.

    • Detect thyroid inflammation, iodine imbalances, and tumours.

    No, fasting is not required for an Extended Thyroid Profile test.

    Here’s how you can easily book any blood test or health checkup on our platform:

    • Search for the Test : Look for the Extended Thyroid Profile test in Delhi or at home and choose Orange Health from the list.

    • Review and Confirm : Pick the test, check for any prerequisites, enter your location, and select a convenient time for sample collection.

    • Sample Collection : A trained eMedic will visit your home to collect the sample at the appointed time.

    • Lab Processing : The sample will be analysed at our ICMR-approved, NABL-accredited lab.

    • Receive Results : Your test results will be shared via email or WhatsApp within 6 hours and can also be accessed via our app.

    The normal levels for an Extended Thyroid Profile are:

    • FT3: 2.77-5.27 pg/mL

    • FT4: 0.78-2.19 ng/dL

    • Total T3: 0.97-1.69 ng/mL

    • Total T4: 5.53-11.0 µg/dL

    • TSH: 0.400-4.049 µIU/mL

    However, for pregnant women, the reference ranges for TSH levels vary by trimester, as follows:

    • 1st Trimester: 0.100 - 2.500 µIU/mL

    • 2nd Trimester: 0.200 - 3.000 µIU/mL

    • 3rd Trimester: 0.300 - 3.000 µIU/mL

    Following your booking of the Extended Thyroid Profile test, an eMedic from Orange Health Labs will come to collect your sample within 60 minutes. The collection typically takes only a few minutes. Your test results will be provided online within 6 hours.

    The need for the Extended Thyroid Profile test varies based on your health needs. Always follow your doctor’s guidance on how frequently you should undergo the test, depending on your health condition.

    The Extended Thyroid Profile test includes the following 5 parameters:

    • Free T3

    • Total T3

    • Free T4

    • Total T4

    • TSH

    With Orange Health, you can get the Extended Thyroid Profile test quickly and conveniently at home throughout Delhi, without needing to visit a physical lab. Our services cover multiple localities, including but not limited to Connaught Place, Chandni Chowk, Karol Bagh, Lajpat Nagar, South Extension, Greater Kailash, Hauz Khas, Saket, Vasant Kunj, Dwarka, Janakpuri, Rajouri Garden, Rohini, Pitampura, Mayur Vihar, Preet Vihar, Shahdara, Laxmi Nagar, Green Park, Safdarjung Enclave, Defence Colony, New Friends Colony, Kalkaji, Malviya Nagar, Nehru Place.

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    References

    1. Thyroid Tests [Internet]. MedlinePlus.  Available from:  https://medlineplus.gov/thyroidtests.html
    2. Thyroid function tests [Internet]. Health Direct.  Available from:  https://www.healthdirect.gov.au/thyroid-function-tests
    3. Thyroid Hormone [Internet]. Cleveland Clinic.  Available from:  https://my.clevelandclinic.org/health/articles/22391-thyroid-hormone
    4. Thyroid Tests [Internet]. Cleveland Clinic.  Available from:  https://my.clevelandclinic.org/health/diagnostics/17556-thyroid-blood-tests