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    NIPT for All Chromosomes217261100049% off
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    What Is a NIPT for All Chromosomes Test?

    Non-Invasive Prenatal Testing (NIPT) is a blood test that helps detect whether a baby is at higher risk of certain genetic conditions during pregnancy. Tiny pieces of the baby’s DNA (cell-free DNA or cfDNA), sourced from the placenta, are found in the mother’s bloodstream. NIPT analyses these fragments to identify chromosomal abnormalities in the foetus without requiring invasive methods like amniocentesis (which tests amniotic fluid) or chorionic villus sampling (CVS, which tests placental tissue). This allows for the detection of conditions linked to extra or missing chromosomes.

    NIPT is mainly used to screen for:

    • Trisomies : The presence of an additional chromosome, such as Trisomy 21 (Down syndrome), Trisomy 18 (Edwards syndrome), and Trisomy 13 (Patau syndrome).

    • Sex chromosome aneuploidies : Abnormal numbers of X or Y chromosomes, including Turner syndrome, Klinefelter syndrome, and Triple X syndrome.

    • Microdeletions : Some tests also check for microdeletions such as 22q11.2.

    NIPT’s advantage over other tests is that it is non-invasive and requires only a blood sample, unlike other procedures for detecting chromosomal abnormalities, which are more invasive. NIPT is a screening tool that estimates the risk but does not confirm a diagnosis. If the test indicates a high risk, further confirmatory tests like amniocentesis or CVS may be recommended. For those in Delhi, the NIPT test offers the convenience of home collection and fast results.

    NIPT for All Chromosomes Test Parameters

    NIPT measures two critical parameters: chromosomal abnormalities (such as Down syndrome – Trisomy 21, Trisomy 18, and Trisomy 13) and sex chromosome abnormalities (like Klinefelter syndrome, Turner syndrome, Triple X syndrome, and XYY syndrome).

    NIPT works by analysing cfDNA, which are small fragments of the baby’s DNA present in the mother’s blood, to detect genetic conditions. These DNA fragments come from the placenta, which is responsible for delivering oxygen and nutrients to the foetus. Typically performed after the 10th week of pregnancy, NIPT provides accurate results once enough foetal DNA has entered the maternal bloodstream.

    The test is highly accurate for detecting Down syndrome (99%), though it is slightly less reliable for conditions such as Trisomy 18 and Trisomy 13. Factors like carrying twins, being a surrogate, or maternal obesity can affect the results.

    For optimal results, the foetal fraction – the percentage of cfDNA in the mother’s blood from the placenta – should be at least 4%. If there isn’t enough foetal DNA, the test may not be able to produce accurate results. This could happen if the test is done too early, if the sample is compromised, or if the mother is overweight. Different NIPT methods may analyse cfDNA in various ways, though most count all cfDNA fragments to identify chromosomal abnormalities.

    NIPT for All Chromosomes Test Preparation

    To achieve reliable results, please follow these guidelines before undergoing the NIPT test:

    • Prerequisites: There are no special preparations needed, such as fasting, prior to the NIPT test.

    • Recommended Time for Testing: The NIPT test can be performed at any time during the day. It is usually recommended after the 10th week of pregnancy, as foetal DNA levels are typically too low before this time.

    • Who Should Take the NIPT Test? This test is advised for pregnant individuals who are at a higher risk of having a child with chromosomal abnormalities. It is also offered to all pregnant individuals.

    • Precautions Before the NIPT Test: There are no specific precautions to be taken before having the NIPT test.

    Why Take the NIPT for All Chromosomes Test?

    NIPT is recommended in pregnant individuals where the foetus may be at risk of genetic conditions, for example:

    NIPT is recommended for pregnant individuals where there may be a higher risk of genetic conditions, including:

    • Pregnant individuals of all risk levels : Initially suggested only for high-risk pregnancies, NIPT is now advised for all pregnant individuals, irrespective of their risk level.

    • Parents with a history of genetic conditions : Individuals who have had a child with a chromosomal abnormality may consider NIPT to assess the risk of similar conditions in their current pregnancy.

    • Individuals with abnormal ultrasound results : If an ultrasound reveals potential developmental abnormalities, NIPT can be used to evaluate the risk of certain genetic disorders .

    • People with abnormal early screening results : If earlier prenatal tests indicate potential problems, NIPT can offer more accurate results regarding chromosomal abnormalities.

    • Expecting parents seeking a comprehensive genetic screening : As genetic testing continues to advance, NIPT can now detect a broader range of genetic disorders, offering important early insights for prenatal care.

    NIPT can accurately detect common chromosomal disorders like Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), and Patau syndrome (trisomy 13), with an accuracy of 94-99%. It can also detect sex chromosome abnormalities such as Turner syndrome (missing an X chromosome) and Klinefelter syndrome (extra X chromosome in males).

    FAQs on the NIPT for All Chromosomes Test in Delhi

    The NIPT test in Delhi is available for ₹11000. This includes home sample collection within 60 minutes of booking, and the test results will be delivered within 287 hours of sample collection.

    Yes, Orange Health Labs offers doorstep sample collection for NIPT testing. Once you schedule the test, a trained eMedic expert will reach your location within 60 minutes to collect the necessary sample.

    NIPT is used to detect genetic disorders, such as Down syndrome, Edwards syndrome, and Patau syndrome, and conditions related to sex chromosomes, like Klinefelter syndrome. It provides an assessment of chromosomal risk factors during pregnancy.

    No fasting is necessary before the NIPT test.

    Here’s how to schedule an NIPT test with Orange Health Labs:

    • Find the Test : Search for “NIPT test” and pick Orange Health Labs from the available options.

    • Confirm Appointment : Enter your details, choose your location, and select a convenient time for sample collection.

    • Sample Collection : A trained eMedic will visit your location to collect the blood sample.

    • Processing and Results : Your sample will be analysed at our NABL-certified, ICMR-approved laboratory. Results will be shared via email or WhatsApp within 287 hours.

    The NIPT results are presented as a "Z score." A Z score falling within the specified range for each condition typically indicates a low risk for that condition. For example, a Z score between -6 and 2.8 is considered low risk for Down syndrome.

    You can expect the test results within 287 hours after the sample has been collected.

    The requirement and frequency of this test are tailored to your particular medical condition and the advice provided by your doctor.

    Included in the NIPT test are screenings for trisomy 21 (Down syndrome), trisomy 18, trisomy 13, as well as sex chromosome conditions like Klinefelter syndrome, Turner syndrome, Triple X syndrome, and XYY syndrome.

    The NIPT test is accessible in various localities across Delhi, including but not limited to Chandni Chowk, Connaught Place, Defence Colony, Dwarka, Greater Kailash, Green Park, Hauz Khas, Janakpuri, Rajouri Garden, Rohini, Safdarjung Enclave, Shahdara, South Extension, Kalkaji, Karol Bagh, Lajpat Nagar, Malviya Nagar, Mayur Vihar, Nehru Place, Preet Vihar, and Vasant Kunj.

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    References

    1. Cleveland Clinic. NIPT test (Noninvasive Prenatal Testing): What To Expect.  Available from:  https://my.clevelandclinic.org/health/diagnostics/21050-nipt-test
    2. Medline Plus. What is noninvasive prenatal testing (NIPT) and what disorders can it screen for?: MedlinePlus Genetics  Available from:  https://medlineplus.gov/genetics/understanding/testing/nipt/
    3. Non-invasive Prenatal Screening or Testing (NIPS / NIPT).  Available from:  https://me.health.gov.il/en/parenting/planning-a-family/pregnancy-testing-and-monitoring/tests-during-pregnancy/nipt-test/
    4. Prenatal Screening and Diagnostic Considerations for 22q11.2 Microdeletions. Genes.  Available from:  https://www.mdpi.com/2073-4425/14/1/160